Enantioselective Iridium Catalyzed Phthalide Formation via Internal Redox Allylation of Phthalaldehydes **
Enantioselective Iridium Catalyzed Phthalide Formation via Internal Redox Allylation of Phthalaldehydes **
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DOI：
10.1002/ange.201712015
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Allylation of Phthalaldehydes;James M Cabrera;Dr. Johannes Tauber;M. Krische
中科院分区：
文献类型：
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作者：
Allylation of Phthalaldehydes;James M Cabrera;Dr. Johannes Tauber;M. Krische
通过邻苯二甲醛的内氧化还原烯丙基化实现对映选择性的苯酞合成。通过还原羰基加成平衡氧化酯化，以实现总体氧化还原中性过程。利用该方法，实现了对映螺环辛甲醚和CJ-12,954的形式化合成。
Enantioselective phthalide synthesis is achieved through internal redox allylation of o-phthalaldehydes. Oxidative esterification is balanced by reductive carbonyl addition to achieve an overall redox neutral process. Using this method, formal syntheses of ent-spirolaxine methyl ether and CJ-12,954 are achieved.