Effects of locally administered insulin on bone formation in non-diabetic rats
Effects of locally administered insulin on bone formation in non-diabetic rats
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DOI：
10.1002/jbm.a.34313
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发表时间：
2013-01-01
影响因子：
4.9
通讯作者：
Westerlund, A.
中科院分区：
文献类型：
--
作者：
Malekzadeh, B.;Tengvall, P.;Westerlund, A.
控制骨形成的可能性在许多医学领域是有利的，在这些领域，骨缺陷仍然是一个主要挑战。胰岛素已被认为在骨组织中发挥全身和局部合成代谢作用。这就提出了一个问题，局部给药胰岛素是否能为局部骨缺损和骨愈合受损的患者提供新的治疗策略。本研究的目的是评估非糖尿病大鼠在局部注射胰岛素时骨形成的情况。本研究与以往报道的不同之处在于两个方面：使用非糖尿病动物和局部给药胰岛素。将24个植入物分别植入12只胰岛素涂层大鼠和1只对照大鼠的胫骨中，持续4周。干涉测量法和组织形态测量法分别用于评估表面形貌和骨形成。结果显示胰岛素固定后表面形貌无明显变化。组织形态学测量显示，与对照组相比，胰岛素包覆种植体周围的骨（BA） （p = 0.005）和种植体表面的骨（BIC）数量相似（p = 0.117）。由此得出结论，从钛种植体表面局部注射胰岛素不仅对糖尿病患者而且对非糖尿病患者都有促进骨形成的潜力。(C) 2012 Wiley期刊公司[J] .中国生物医学工程学报，2016,31(1):1 - 4。
The possibility to control bone formation would be favorable in many areas of medicine, where bone defects is still a major challenge. Insulin has been suggested to exert both systemic and local anabolic effects in bone tissues. This raised the question whether locally administrated insulin could provide new therapeutic strategies for patients with local bone defects and impaired bone healing. The aim of this study was to evaluate bone formation in non-diabetic rats when local insulin is administered. This study differs from previous reports in two aspects: the use of non-diabetic animals and locally administered insulin. Twenty-four implants were inserted into 12 ratsone insulin-coated and one controlin each tibia for four weeks. Interferometry and histomorphometry were used to evaluate the surface topography and bone formation, respectively. Results demonstrated no significant changes in surface topography after insulin immobilization. Histomorphometry revealed significantly more bone around the insulin-coated implants (BA) (p = 0.005) and a similar amount of bone at the implant surface (BIC) (p = 0.117) compared with the controls. It was concluded that locally administered insulin from a titanium implant surface has the potential to increase bone formation not only in diabetic subjects but also in non-diabetic subjects. (C) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A:132137, 2013.