Estrogens and development.
Estrogens and development.
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DOI：
10.1289/ehp.877525
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发表时间：
1987-11
影响因子：
10.4
通讯作者：
Newbold RR
中科院分区：
文献类型：
--
作者：
McLachlan JA;Newbold RR
包括人类在内的哺乳动物的生殖器官的正常发育是在激素的控制下进行的。女性性激素雌激素在这一过程中的作用尚不清楚。然而，实验动物或人类暴露于有效的外源性雌激素己烯雌酚（DES），导致持续的分化效应。由于环境中的许多化学物质具有弱雌激素性，因此必须考虑生殖分化改变的可能性。
The normal development of the genital organs of mammals, including humans, is under hormonal control. A role for the female sex hormone estrogen in this process is still unclear. However, exposure of experimental animals or humans to the potent exogenous estrogen, diethylstilbestrol (DES), results in persistent differentiation effects. Since many chemicals in the environment are weakly estrogenic, the possibility of hormonally altered differentiation must be considered.