Effect of flecainide on cardiac output
Effect of flecainide on cardiac output
复制标题
氟卡尼对心输出量的影响
DOI：
10.1038/clpt.1985.37
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发表时间：
1985
影响因子：
6.7
通讯作者：
A. Blackett
中科院分区：
文献类型：
--
作者：
K. Muhiddin;P. Turner;A. Blackett
在6名健康非吸烟者中，通过染料稀释法评价静脉注射氟卡尼（2 mg/kg）对心输出量的影响。本研究采用双盲、交叉、安慰剂对照、随机和平衡设计。开始输注氟卡尼后0、10、30、60、90、120、150、180和240分钟测量心输出量、心率和每搏输出量。氟卡尼在给药后的前90分钟内降低了心输出量和每搏输出量，在给药后的前30分钟内心率增加。在给药后0、10、60和240分钟测定警觉性和口干的视觉模拟量表。服用氟卡尼60分钟后，警觉性降低，但口干没有增加。
The effect of intravenous flecainide (2 mg/kg) on cardiac output was evaluated by a dye dilution method in six healthy nonsmokers. The study was of a double‐blind, crossover, placebo‐controlled, randomized, and balanced design. Cardiac output, heart rate, and stroke volume were measured 0, 10, 30, 60, 90, 120,150, 180, and 240 minutes after the beginning of the flecainide infusion. Flecainide reduced cardiac output and stroke volume during the first 90 minutes and heart rate increased during the first 30 minutes after flecainide. Visual analog scales for alertness and dry mouth were determined 0, 10, 60, and 240 minutes after dosing. Alertness was reduced 60 minutes after flecainide, but there was no increase in dryness of the mouth.