MicroRNA-Mediated Host-Pathogen Interactions Between Bombyx mori and Viruses.
MicroRNA-Mediated Host-Pathogen Interactions Between Bombyx mori and Viruses.
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DOI：
10.3389/fphys.2021.672205
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发表时间：
2021
影响因子：
4
通讯作者：
Sun J
中科院分区：
文献类型：
--
作者：
Awais MM;Shakeel M;Sun J
MicroRNA（miRNAs）是一类约22个核苷酸的非编码小RNA，在转录后水平调控基因表达，参与免疫、发育、代谢和宿主-病原体相互作用等多种生物学过程。除了由宿主编码的miRNAs外，病原体产生的miRNAs还调节宿主基因以促进病毒复制和逃避宿主防御反应。近年来的研究表明，病毒感染改变了宿主miRNAs的表达谱，细胞和病毒miRNAs在宿主-病原体相互作用中均发挥重要作用。家蚕是重要的鳞翅目模式种之一，也是重要的经济丝绸生产昆虫。B之间相互作用的机制。家蚕及其病原体及其通过miRNAs的调控已被广泛研究。因此，本文就病毒编码的miRNAs及其调控病毒和宿主（B. mori）基因。此外，B.还讨论了桑源miRNAs与病毒感染的关系。对miRNAs在B中的调控作用进行了详细的评述。Mori病毒的相互作用将帮助我们了解分子网络，并制定可持续的抗病毒策略。
MicroRNAs (miRNAs), small non-coding RNAs of about 22 nucleotides, have been reported to regulate gene expression at the posttranscriptional level and are involved in several biological processes such as immunity, development, metabolism, and host-pathogen interactions. Apart from miRNAs encoded by the host, miRNAs produced by pathogens also regulate host genes to facilitate virus replication and evasion of the host defense responses. In recent years, accumulated studies suggest that viral infections alter the host miRNAs expression profile, and both cellular and viral miRNAs may play vital roles in host-pathogen interactions. Bombyx mori, one of the critical lepidopteran model species, is an economically important insect for silk production. The mechanism of interaction between B. mori and its pathogens and their regulation by miRNAs has been extensively studied. Therefore, in this review, we aim to highlight the recent information and understanding of the virus-encoding miRNAs and their functions in modulating viral and host (B. mori) genes. Additionally, the response of B. mori derived miRNAs to viral infection is also discussed. A detailed critical view about miRNAs’ regulatory roles in B. mori-virus interactions will help us understand molecular networks and develop a sustainable antiviral strategy.
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