Challenges to Maternal Wellbeing during Pregnancy Impact Temperament, Attention, and Neuromotor Responses in the Infant Rhesus Monkey
Challenges to Maternal Wellbeing during Pregnancy Impact Temperament, Attention, and Neuromotor Responses in the Infant Rhesus Monkey
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DOI：
10.1002/dev.20489
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发表时间：
2010-11-01
影响因子：
2.2
通讯作者：
Schneider, Mary L.
中科院分区：
文献类型：
--
作者：
Coe, Christopher L.;Lubach, Gabriele R.;Schneider, Mary L.
婴儿出生时的相对成熟度、警觉性和反应性是新生儿健康、妊娠质量和母亲幸福的敏感指标。即使胎儿的生长和妊娠时间是正常的，成熟的胎儿仍然会受到产前期间母亲的身体事件和心理挑战的不利影响。接下来的研究评估了来自7种不同妊娠类型的413只恒河猴，以确定哪些条件会显著影响幼儿的行为反应和状态。采用了以人类新生儿的新生儿行为评估量表为模型的标准化测试量表。当雌性猴子饮酒时，即使在怀孕期间只喝了适度的酒精，也会出现定向力的最大障碍和Want情绪反应的增加。当妊娠女性的肾上腺激素短暂升高2周时，婴儿的注意力集中和注意视觉和听觉线索的能力也受到影响。此外，触觉和前庭刺激的反应改变了这两个ACTH治疗和妊娠期间的心理障碍。相反，在足月前1个月使用2天的皮质类固醇导致婴儿的运动活动和反应性降低。这些发现突出了几种可能影响幼儿神经行为状态的妊娠条件，即使在其他方面健康，并表明改变或缺陷是特定于母亲和胎儿所经历的侮辱类型。(C)2010 Wiley，Periodicals，Inc. Dev Psychobiol 52：625-637，2010.
The relative maturity, alertness, and reactivity of an infant at birth are sensitive indices of the neonate's health, the quality of the pregnancy, and the mother's wellbeing. Even when fetal growth and gestation length have been normal, the maturing fetus can still be adversely impacted by both physical events and psychological challenges to the mother during the prenatal period. The following research evaluated 413 rhesus monkeys from 7 different types of pregnancies to determine which conditions significantly influenced the behavioral responsiveness and state of the young infant. A standardized test batter), modeled after the Neonatal Behavioral Assessment Scale for human newborns was employed. The largest impairments in orientation and increases in Want emotional reactivity were seen when female monkeys drank alcohol, even though consumed at only moderate levels during part of the pregnancy. The infants' ability to focus and attend to visual and auditory cues was also affected when the gravid female's adrenal hormones were transiently elevated for 2 weeks by ACTH administration. In addition, responses to tactile and vestibular stimulation were altered by both this ACTH treatment and psychological disturbance during gestation. Conversely, a 2-day course of antenatal corticosteroids 1 month before term resulted in infants with lower motor activity and reactivity. These findings highlight several pregnancy conditions that can affect a young infant's neurobehavioral status, even when otherwise healthy, and demonstrate that alterations or deficits are specific to the type of insult experienced by the mother and fetus. (C) 2010 Wiley, Periodicals, Inc. Dev Psychobiol 52: 625-637, 2010.