Hypertriglyceridemia in a Pediatric Referral Practice: Experience With 300 Patients
Hypertriglyceridemia in a Pediatric Referral Practice: Experience With 300 Patients
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DOI：
10.1177/0009922810379498
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发表时间：
2011-04-01
影响因子：
1.6
通讯作者：
Osganian, Stavroula K.
中科院分区：
文献类型：
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作者：
de Ferranti, Sarah D.;Crean, Sheila;Osganian, Stavroula K.
背景：小儿高甘油三酯血症是儿童肥胖的一种新出现的合并症。方法：本研究回顾性回顾了医疗记录，描述了儿科预防心脏病诊所跟踪的 300 名高危儿童的特征和临床病程。结果：平均基线甘油三酯 (TG) 水平为 269 mg/dL (SD 342 mg/dL)； 91% 的 TG 水平在 150 至 399 mg/dL 之间。总共 77% 的人超重/肥胖，23% 的人血压升高，23% 有高甘油三酯家族史，11% 的人报告有精神病诊断（其中 33.3% 的人有严重的 TG 升高）。饮食和活动改变是一线疗法；很少有人服用降脂药物（基线，5.1%；随访，11.4%）。 TG 水平下降 23%（平均 88 mg/dL；SD 231），通常伴随 TG 风险类别的下降或稳定。体重指数较低的儿童（< 85% 性别和年龄匹配百分位）比较重的儿童（70% vs 40%；P
Background: Pediatric hypertriglyceridemia is an emerging comorbidity of childhood obesity. Methods: This study reviewed medical records retrospectively to describe the characteristics and clinical course of 300 at-risk children followed in a pediatric preventive cardiology clinic. Results: Average baseline triglyceride (TG) level was 269 mg/dL (SD 342 mg/dL); 91% had TG levels between 150 and 399 mg/dL. A total of 77% were overweight/obese, 23% had elevated blood pressure, 23% had a family history of high triglycerides, and 11% reported a psychiatric diagnosis (33.3% of those with severe TG elevations). Diet and activity change were the first-line therapies; few were taking lipid-lowering medications (baseline, 5.1%; follow-up, 11.4%). TG levels declined by 23% (average, 88 mg/dL; SD 231), often with a decline or plateau in TG risk category. Children with a lower body mass index (< 85% gender- and age-matched percentile) were more likely to improve in TG category than heavier children (70% vs 40%; P