Studying vascular progenitor cells in a neonatal mouse model.
Studying vascular progenitor cells in a neonatal mouse model.
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研究新生小鼠模型中的血管祖细胞。
DOI：
10.1007/978-1-61779-943-3_19
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Hirschi,KarenK
中科院分区：
文献类型：
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作者：
Kienstra,KirstenA;Hirschi,KarenK
虽然已经开发了许多小鼠模型来研究成人疾病，但专注于新生儿和儿科医学的动物研究受到小鼠幼崽尺寸小的限制。几种移植、注射和植入系统已被用于研究成年小鼠血管祖细胞群的功能和作用;然而，这些技术难以转化为新生动物。在此，我们描述了一种新生鼠血管内注射模型，该模型为研究新生儿特有的许多疾病提供了机会，这些疾病可能受益于血管修复策略和再生医学。
While many murine models have been developed to study adult disease, animal research focused on neonatal and pediatric medicine has been limited by the small size of the mouse pups. Several transplantation, injection, and implantation systems have been used to study the function and role of vascular progenitor populations in adult mice; however, such techniques have been difficult to translate into newborn animals. Herein, we describe a model of neonatal murine intravascular injections that opens opportunity to study many diseases unique to the newborn that might benefit from vascular repair strategies and regenerative medicine.