Neither retinal nor brain atrophy can be shown in patients with isolated unilateral optic neuritis at the time of presentation
Neither retinal nor brain atrophy can be shown in patients with isolated unilateral optic neuritis at the time of presentation
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DOI：
10.1177/1352458510382017
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Frederiksen, Jette L.
中科院分区：
文献类型：
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作者：
Kallenbach, Klaus;Sander, Birgit;Frederiksen, Jette L.
背景：急性单症状性视神经炎（ON）可能是多发性硬化症（MS）的最早表现。萎缩已被证明是MS的一个突出特征，对残疾有很大的影响。目的：本研究的目的是评估ms早期视网膜和脑萎缩及其可能的关联。方法：在一项前瞻性观察队列研究中，我们纳入了60例未经治疗的单症状性ON患者和19名健康志愿者。未受影响的同伴用光学相干断层扫描（OCT）检查眼睛，并根据MRI计算归一化脑体积。同时记录视觉诱发电位（vep）。结果：与健康志愿者相比，OCT测量和脑容量测量均未显示患者局部或全身性萎缩的迹象。根据白质病变的存在将患者分层为高风险并没有显示出差异。先前发现的OCT测量与脑容量之间的关联在首次临床事件发生时无法得到证实。与没有病变的患者相比，有白质病变的患者VEP潜伏期明显延长。研究人员注意到，同伴眼睛的副电位振幅与脑容量之间存在一种趋势。结论：在这个队列中，我们无法显示视网膜或大脑的萎缩特征，并且在MS晚期显示的视网膜和大脑结构测量之间的关联无法重现。这些发现表明，萎缩确实需要时间来进化，并表明局部和一般结构措施之间关系的复杂性。
Background: Acute monosymptomatic optic neuritis (ON) may be the earliest manifestation of multiple sclerosis (MS). Atrophy has been shown to be a prominent feature of MS with great impact on disability.Objectives: The objectives of this study were to evaluate retinal and brain atrophy and possible associations at the earliest possible stages of MS.Methods: In a prospective observational cohort study we included 60 untreated patients with monosymptomatic ON and 19 healthy volunteers. Unaffected fellow eyes were examined with optical coherence tomography (OCT) and normalized brain volumes were calculated based on MRI. Additionally, visual evoked potentials (VEPs) were recorded.Results: Neither OCT measurements nor brain volume measures revealed signs of localized or generalized atrophy in patients compared with healthy volunteers. Stratification of patients into high risk based on the presence of white matter lesions did not reveal differences. The association between OCT measures and brain volumes previously found could not be confirmed at the time of the first clinical event. VEP latency was significantly prolonged in patients with white matter lesions compared to those without lesions. A trend towards a relationship between VEP amplitude of fellow eyes and brain volumes was noted.Conclusions: In this cohort we were not able to show atrophic features in the retina or the brain, and the association between structural measures of the retina and the brain as indicated in the later stages of MS could not be reproduced. These findings suggest that atrophy does require time to evolve and indicate the complexity of the relationship between local and general structural measures.