Speculations on the origin of the genetic code
Speculations on the origin of the genetic code
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DOI：
10.1007/bf00166623
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发表时间：
1995-05
影响因子：
3.9
通讯作者：
H. Hartman
中科院分区：
文献类型：
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作者：
H. Hartman
最原始的密码被认为是GC密码：GG编码甘氨酸，CC编码脯氨酸，GC编码丙氨酸，CG编码“精氨酸”。遗传密码被认为起源于甘氨酸与其反密码子CC通过铜蒙脱石介导的偶联。当聚脯氨酸与其反密码子GG偶联时，聚脯氨酸随后聚合。在这种情况下，氨酰-tRNA合成酶是铜蒙脱石。第一个膜被认为是由聚甘氨酸形成的β折叠。随着密码变得越来越复杂，交替的疏水-亲水多肽（丙氨酸-“精氨酸”）由交替的CG共聚物编码。这种交替的多肽（ala-“arg”）开始起原始膜和氨酰-tRNA合成酶的作用。蛋白质结构的进化与膜的进化紧密相连。当脂质成为生物膜结构的一部分时，α螺旋就进化了。膜最终变成了现在普遍存在的流体镶嵌结构。
The most primitive code is assumed to be a GC code: GG coding for glycine, CC coding for proline, GC coding for alanine, CG coding for “arginine.” The genetic code is assumed to have originated with the coupling of glycine to its anticodon CC mediated by a copper-montmorillonite. The polymerization of polyproline followed when it was coupled to its anticodon GG. In this case the aminoacyl-tRNA synthetase was a copper-montmorillonite. The first membrane is considered to be a β sheet formed from polyglycine. As the code grew more complicated, the alternative hydrophobic-hydrophilic polypeptide (alanine-“arginine”) was coded for by the alternating CG copolymer. This alternating polypeptide (ala-“arg”) began to function as both a primitive membrane and as an aminoacyl-tRNA synthetase. The evolution of protein structure is tightly coupled to the evolution of the membrane. The a helix was evolved as lipids became part of the structure of biological membranes. The membrane finally became the fluid mosaic structure that is now universal.