Verumontanum mucosal gland hyperplasia.
Verumontanum mucosal gland hyperplasia.
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Verumontanum粘膜腺增生。
DOI：
10.1097/00000478-199501000-00004
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Wheeler,TM
中科院分区：
文献类型：
--
作者：
Gagucas,RJ;Brown,RW;Wheeler,TM
小腺泡型前列腺癌可模拟为良性增生性病变，如非典型腺瘤性增生(腺病)、硬化性腺病、结节状增生(细胞区)、小叶增生、基底细胞增生、中肾增生和肾源性腺瘤。在我们的研究中，我们描述了另一种微腺泡增生，我们称之为外粘膜腺体增生症(VMGH)，因为它仅发生在外和邻近的后尿道处，射精管和椭圆囊排空进入尿道处。我们回顾了1988年至1993年分别为前列腺癌和膀胱癌施行的341例根治性前列腺切除术和膀胱前列腺切除术。47~87岁患者中49例(14%)有VMGH病灶。88个病灶中，单发19个，多发30个。59个病灶位于射精管或前列腺管周围，17个位于椭圆囊周围，1个位于邻近的后尿道粘膜。根据每个病灶的腺泡数量进行量化如下：28个病灶中6-10个(1+)。29例(2+)中11至25例，16例(3+)中25至50例，15例(4+)中超过50例。未见结晶体或腔内粘蛋白，但88个病灶中有57个可见腔内淀粉样体，通常数量较多。在建筑上，微腺经常是“背靠背”的。衬里上皮由平淡的立方到柱状的腔上皮细胞和下面的基底层细胞组成。VMGH是一种以前未被描述的良性微腺泡增生，发生在一个非常有限和特定的位置，似乎与其他可能被混淆的病变无关。
Prostatic adenocarcinoma of the small acinar type can be mimicked be benign proliferative lesions, such as atypical adenomatous hyperplasia (adenosis), sclerosing adenosis, nodular hyperplasia (cellular areas), lobular hyperplasia, basal cell hyperplasia, mesonephric hyperplasia, and nephrogenic adenoma. In our study, we describe another microacinar proliferation, which we have termed verumontanum mucosal gland hyperplasia (VMGH) because it occurs exclusively in the verumontanum and adjacent posterior urethra where the ejaculatory ducts and utricle empty into the urethra. We reviewed 341 radical prostatectomies and cystoprostatectomies done from 1988 through 1993 for prostate and bladder carcinoma, respectively. Forty-nine prostates (14%) from patients aged 47 to 87 contained foci of VMGH. Of a total of 88 foci, a single lesion was present in 19 cases and multiple lesion in 30 cases. Fifty-nine of the foci arose around the ejaculatory or prostatic ducts, 17 from around the utricle, and 1 [kappa] from adjacent posterior urethral mucosa. Individual lesions were quantified as to the number of acini per focus as follows: 6 to 10 in 28 (1+). 11 to 25 in 29 (2+), 25 to 50 in 16 (3+), and more than 50 in 15 (4+). No crystalloids or intraluminal mucin were seen, but: intraluminal corpora amylacea, usually numerous, were present in 57 of the 88 foci. The microacini were frequently" back to back" architecturally. The lining epithelium consisted of bland cuboidal to columnar luminal cells with underlying basal cells. VMGH, a previously undescribed benign microacinar proliferation, occurs in a very restricted and specific location and appears to be unrelated to other lesions with which it may be confused.