Oxidants and skeletal muscle function: Physiologic and pathophysiologic implications
Oxidants and skeletal muscle function: Physiologic and pathophysiologic implications
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DOI：
10.1046/j.1525-1373.1999.d01-142.x
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发表时间：
1999-12-01
影响因子：
--
通讯作者：
Klawitter, P
中科院分区：
文献类型：
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作者：
Clanton, TL;Zuo, L;Klawitter, P
先前的研究表明，骨骼肌在剧烈的肌肉收缩过程中产生大量的活性氧。然而，这种现象的意义以及它是否代表正常的生理或病理学知之甚少。用外源性抗氧化剂治疗表明，收缩期间的正常氧化还原张力正在影响正在进行的收缩功能，无论是在休息时还是在剧烈运动时，这可能代表负责兴奋-收缩偶联的氧化还原敏感蛋白或氧化还原敏感代谢酶的影响，与剧烈运动相关的一些状况，如局部组织缺氧或组织温度升高，也会促进活性氧的产生。有证据表明，肌肉调节导致抗氧化防御上调，也表明活性氧和收缩活动之间的密切关系。因此，活性氧在正常肌肉生理学中似乎具有重要作用。然而，许多条件可能导致氧化剂产生和抗氧化剂防御的不平衡，并且这些条件可能确实产生氧化应激条件。缺血-再灌注、严重缺氧、严重热应激、脓毒性休克和牵张诱导的损伤都可能导致氧化剂介导的对肌细胞的损伤，导致机械功能障碍。
Previous studies have demonstrated that skeletal muscles generate considerable reactive oxygen during intense muscle contraction. However, the significance of this phenomenon and whether it represents normal physiology or pathology are poorly understood. Treatment with exogenous antioxidants suggests that normal redox tone during contraction is influencing ongoing contractile function, both at rest and during intense exercise, This could represent the influence of redox-sensitive proteins responsible for excitation-contraction coupling or redox-sensitive metabolic enzymes, Some conditions associated with intense exercise, such as local tissue hypoxia or elevated tissue temperatures, could also contribute to reactive oxygen production. Evidence that muscle conditioning results in upregulation of antioxidant defenses also suggests a close relationship between reactive oxygen and contractile activity. Therefore, there appears to be a significant role for reactive oxygen in normal muscle physiology, However, a number of conditions may lead to an imbalance of oxidant production and antioxidant defense, and these, presumably, do create conditions of oxidant stress, Ischemia-reperfusion, severe hypoxia, severe heat stress, septic shock, and stretch-induced injury may all lead to oxidant-mediated injury to myocytes, resulting in mechanical dysfunction.