Stimulation of category-selective brain areas modulates ERP to their preferred categories.
Stimulation of category-selective brain areas modulates ERP to their preferred categories.
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刺激类别选择性大脑区域可将 ERP 调节至其偏好的类别。
DOI：
10.1016/j.cub.2011.09.030
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Sadeh B
中科院分区：
文献类型：
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作者：
Sadeh B
功能性MRI[1-3]和事件相关电位（event- correlation potential， ERP）[4,5]都证实了脑外皮层对特定物体类别的神经选择性。在这里，我们测试了类别选择区域的激活与他们偏好类别的ERP之间的因果关系。当参与者观察面部和无头身体时，记录脑电图（EEG）。在记录脑电图的同时，我们在刺激开始后的60和100 ms分别在右侧枕面区（OFA）或枕外体区（EBA）上施加两次经颅磁刺激（TMS）脉冲。结果表明，刺激部位与刺激类别在ERP调制上存在明显的分离：OFA刺激显著增加了对面部的N1振幅，而对身体的N1振幅没有增加；EBA刺激显著增加了对身体的N1振幅，而对面部的N1振幅没有增加。这些发现为类别选择网络的活动和头皮记录的ERP与他们偏好的类别之间的特定因果关系提供了第一个证据。这一结果也表明，面部和身体N1反映了几个不重叠的神经源，而不是单独的面部选择机制的变化。最后，由于早期刺激（60-100 ms）影响了后期ERP组件（150-200 ms）的选择性，结果可能暗示枕叶和颞叶类别选择区域之间存在前馈连接。
Neural selectivity to specific object categories has been demonstrated in extrastriate cortex with both functional MRI [1–3] and event-related potential (ERP) [4, 5]. Here we tested for a causal relationship between the activation of category-selective areas and ERP to their preferred categories. Electroencephalogram (EEG) was recorded while participants observed faces and headless bodies. Concurrently with EEG recording, we delivered two pulses of transcranial magnetic stimulation (TMS) over the right occipital face area (OFA) or extrastriate body area (EBA) at 60 and 100 ms after stimulus onset. Results showed a clear dissociation between the stimulated site and the stimulus category on ERP modulation: stimulation of the OFA significantly increased the N1 amplitude to faces but not to bodies, whereas stimulation of the EBA significantly increased the N1 amplitude to bodies but not to faces. These findings provide the first evidence for a specific and causal link between activity in category-selective networks and scalp-recorded ERP to their preferred categories. This result also demonstrates that the face and body N1 reflects several nonoverlapping neural sources, rather than changes in face-selective mechanisms alone. Lastly, because early stimulation (60–100 ms) affected selectivity of a later ERP component (150–200 ms), the results could imply a feed-forward connection between occipital and temporal category-selective areas.