Extreme Air Pollution Conditions Adversely Affect Blood Pressure and Insulin Resistance: The Air Pollution and Cardiometabolic Disease Study.
Extreme Air Pollution Conditions Adversely Affect Blood Pressure and Insulin Resistance: The Air Pollution and Cardiometabolic Disease Study.
复制标题
DOI：
10.1161/hypertensionaha.115.06237
复制
发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Rajagopalan S
中科院分区：
文献类型：
--
作者：
Brook RD;Sun Z;Brook JR;Zhao X;Ruan Y;Yan J;Mukherjee B;Rao X;Duan F;Sun L;Liang R;Lian H;Zhang S;Fang Q;Gu D;Sun Q;Fan Z;Rajagopalan S
越来越多的证据表明，细颗粒物对心脏代谢疾病有不利影响，特别是对易感人群；然而，亚洲特大城市中的极端浓度对健康的影响并未得到很好的描述。我们招募了65名北京大都市地区患有代谢综合征和胰岛素抵抗的不吸烟成年人，参加了一项小组研究，该研究涵盖了自2012年以来的四个季节的四次重复访问。每日环境中的细颗粒物(PM2.5)和个人黑碳(BC)水平分别为9.0至552.5μg/立方米和0.2至24.5μg/立方米，在2013年1月期间出现了极端水平。前1-7天的PM2.5累积暴露窗口与每标准差增加2.0(95%可信区间0.3-3.7)至2.7(0.6-4.8)μ汞的收缩压升高显著相关，而前2-5天的累积BC暴露与舒张压每标准差升高1.3(0.0-2.5)至1.7(0.3-3.2)毫米汞柱的范围显著相关[3.6μg/m 3]。血糖值和PM2.5与胰岛素抵抗的恶化显著相关(滞后第4天和第5天的血糖值每标准差增加0.18(0.01~0.36)和0.22(0.04~0.39)个单位，环境PM2.5每标准差增加0.18(0.02~0.34)和0.22(0.08~0.36)个单位)。这些结果提供了重要的全球公共卫生警告，即空气污染可能对心脏代谢健康构成风险，即使在当今发展中国家数十亿人面临的极高浓度下也是如此。
Mounting evidence supports that fine particulate matter adversely impacts cardio-metabolic diseases particularly in susceptible individuals; however, health effects induced by the extreme concentrations within megacities in Asia is not well described. We enrolled 65 nonsmoking adults with metabolic syndrome and insulin resistance in the Beijing metropolitan area into a panel study of four repeated visits across four seasons since 2012. Daily ambient fine particulate matter (PM2.5) and personal black carbon (BC) levels ranged from 9.0 to 552.5 μg/m3 and 0.2 to 24.5 μg/m3, respectively, with extreme levels observed during January 2013. Cumulative PM2.5 exposure windows across the prior 1-7 days were significantly associated with systolic blood pressure (BP) elevations ranging from 2.0 (95% confidence interval 0.3-3.7) to 2.7 (0.6-4.8) mmHg per standard deviation increase [67.2 μg/m3]), while cumulative BC exposure during the previous 2-5 days were significantly associated with ranges in elevations in diastolic BP from 1.3 (0.0-2.5) to 1.7 (0.3-3.2) mmHg per standard deviation increase [3.6 μg/m3]). Both BC and PM2.5 were significantly associated with worsening insulin resistance (0.18 (0.01-0.36) and 0.22 (0.04-0.39) unit increase per standard deviation increase of personal-level BC, and 0.18 (0.02-0.34) and 0.22 (0.08-0.36) unit increase per standard deviation increase of ambient PM2.5 on lag days 4 and 5). These results provide important global public health warnings that air pollution may pose a risk to cardio-metabolic health even at the extremely high concentrations faced by billions of people in the developing world today.