Distinct subdivisions of human medial parietal cortex support recollection of people and places
Distinct subdivisions of human medial parietal cortex support recollection of people and places
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DOI：
10.7554/elife.47391
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发表时间：
2019-07-15
期刊：
影响因子：
7.7
通讯作者：
Baker, Chris, I
中科院分区：
文献类型：
--
作者：
Silson, Edward H.;Steel, Adam;Baker, Chris, I
人类内侧顶叶皮层（MPC）参与记忆回忆、视觉场景处理和导航等多种认知过程，是默认模式网络的核心组成部分。在这里，我们展示了MPC的不同分支，这些分支在回忆特定的人或地点时被选择性地招募。首先，MPC的不同区域与腹侧颞叶皮层（VTC）的内侧和外侧区域表现出不同的功能连通性。其次，这些相同的内侧区域对不同刺激类别的视觉呈现表现出选择性但消极的反应，对场景和面孔有明显的偏好。最后，也是最关键的一点是，在回忆熟悉度强的人和地方时，这些区域被不同地调动起来。综上所述，这些数据表明，定义VTC中-外侧轴的组织原则反映在MPC中，但在记忆回忆的背景下。
Human medial parietal cortex (MPC) is implicated in multiple cognitive processes including memory recall, visual scene processing and navigation, and is a core component of the default mode network. Here, we demonstrate distinct subdivisions of MPC that are selectively recruited during memory recall of either specific people or places. First, distinct regions of MPC exhibited differential functional connectivity with medial and lateral regions of ventral temporal cortex (VTC). Second, these same medial regions showed selective, but negative, responses to the visual presentation of different stimulus categories, with clear preferences for scenes and faces. Finally, and most critically, these regions were differentially recruited during memory recall of either people or places with a strong familiarity advantage. Taken together, these data suggest that the organizing principle defining the medial-lateral axis of VTC is reflected in MPC, but in the context of memory recall.