Extra sensory perception: the role of Gpr receptors in the kidney.
Extra sensory perception: the role of Gpr receptors in the kidney.
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DOI：
10.1097/mnh.0000000000000048
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发表时间：
2014-09
影响因子：
3.2
通讯作者：
Pluznick JL
中科院分区：
文献类型：
--
作者：
Pluznick JL
这篇综述将总结近期文献，重点介绍感觉性Gpr受体的作用及其在肾功能中的作用。
化学感受器在肾脏生理学中发挥重要作用，它们根据来自多种来源的配体调节肾功能。
作为特殊的化学探测器，肾脏中的化学感受器的功能是监测体内多种化学配体的水平，并相应地调节肾功能。除了嗅觉受体和味觉受体，孤儿Gpr家族的G蛋白偶联受体现在被发现在肾脏生理学中发挥“感觉”作用。确定这些受体的生理作用，并阐明这些信号通路背后的细胞生物学原理，能够让我们对肾功能有新的认识。
This review will summarize recent literature highlighting the roles of sensory Gpr receptors and their roles in renal function. Chemoreceptors play important roles in renal physiology where they modulate renal function in response to ligands from a variety of sources. As specialized chemical detectors, chemoreceptors in the kidney function to monitor the level of a variety of chemical ligands in the body, and to adjust renal function accordingly. In addition to olfactory receptors and taste receptors, G-protein coupled receptors of the orphan Gpr family are now being found to play a ‘sensory’ role in renal physiology. Identifying the physiological roles of these receptors, and elucidating the cell biology underlying these signaling pathways, can give us novel insights into renal function.