Correlation between neuromelanin-sensitive MR imaging and 123I-FP-CIT SPECT in patients with parkinsonism
Correlation between neuromelanin-sensitive MR imaging and 123I-FP-CIT SPECT in patients with parkinsonism
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DOI：
10.1007/s00234-016-1644-7
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发表时间：
2016-04-01
期刊：
影响因子：
2.8
通讯作者：
Ogawa, Toshihide
中科院分区：
文献类型：
--
作者：
Kuya, Keita;Shinohara, Yuki;Ogawa, Toshihide
神经黑素敏感性磁共振成像（MRI）可以显示黑质丘脑部（SNc）中含有神经黑素的神经元，并且已报道其在帕金森综合征评估中的实用性。相反，通过I-123-N-v-氟丙基-2b-甲氧羰基-3b-（4-碘苯基）去甲托烷（FP-CIT）SPECT（DaTSCAN）进行的多巴胺转运蛋白成像现在是评估帕金森综合征、检测突触前多巴胺神经元功能障碍的既定方法。这两种方法都可以帮助区分神经退行性和其他形式的帕金森病。然而，据我们所知，还没有关于这两种方法之间相关性的研究。本研究的目的是评估神经黑素敏感MRI诊断帕金森综合征的实用性，通过检查与DaTSCAN的相关性。23例帕金森综合征患者接受了神经黑素敏感MRI和DaTSCAN。我们通过在神经黑色素敏感MRI上手动勾画SNc的高信号强度区域来测量神经黑色素阳性SNc区域体积，并在DaTSCAN上测量特异性结合率（SBR）。计算神经黑素阳性SNc区域体积的不对称指数和特异性结合率（SBR）的不对称指数，神经黑素阳性SNc区域的体积与特异性结合率（SBR）呈显著相关（右侧P < .001，rho = 0.78，左侧P < .001，rho = 0.86）。SNc体积的不对称性指数与SBR的不对称性指数也有显著相关性（P <0.001，rho = 0.73），SNc高信号区的减少提示黑质纹状体多巴胺能功能受损和多巴胺能神经元丢失。我们的结论是神经黑素敏感的MRI是一个有用的诊断帕金森综合征的生物标志物。
Neuromelanin-sensitive MR imaging (MRI) can visualize neuromelanin-containing neurons in the substantia nigra pars compacta (SNc), and its utility has been reported in the evaluation of parkinsonism. Conversely, dopamine transporter imaging by I-123-N-v-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl)nortropane (FP-CIT) SPECT (DaTSCAN) is now an established method for evaluating parkinsonism, detecting presynaptic dopamine neuronal dysfunction. Both methods can assist differentiating neurodegenerative and other forms of parkinsonism. However, to our knowledge, there have been no studies concerning a correlation between the two methods. The aim of this study was to assess the utility of neuromelanin-sensitive MRI for diagnosing parkinsonism by examining a correlation with DaTSCAN.Twenty-three patients with parkinsonism who underwent both neuromelanin-sensitive MRI and DaTSCAN were included. We measured the neuromelanin-positive SNc region volume by manually contouring the high signal intensity region of the SNc on neuromelanin-sensitive MRI and measured the specific binding ratio (SBR) on DaTSCAN. The asymmetry index of neuromelanin-positive SNc volume and the asymmetry index of SBR were also calculated.The volume of the neuromelanin-positive SNc region showed significant correlation with specific binding ratio (SBR) (right P < .001, rho = 0.78, left P < .001, rho = 0.86). The asymmetry index of neuromelanin-positive SNc volume also showed significant correlations with the asymmetry index of SBR (P < .001, rho = 0.73).Decrease of the high signal intensity region of the SNc on neuromelanin-sensitive MRI would indicate damage to the nigrostriatal dopaminergic function as well as loss of dopaminergic neurons. We conclude that neuromelanin-sensitive MRI is a useful diagnostic biomarker for parkinsonism.