A DOMINANT MUTATION THAT PREDISPOSES TO MULTIPLE INTESTINAL NEOPLASIA IN THE MOUSE
A DOMINANT MUTATION THAT PREDISPOSES TO MULTIPLE INTESTINAL NEOPLASIA IN THE MOUSE
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DOI：
10.1126/science.2296722
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发表时间：
1990-01-19
期刊：
影响因子：
56.9
通讯作者：
DOVE, WF
中科院分区：
文献类型：
--
作者：
MOSER, AR;PITOT, HC;DOVE, WF
在用诱变剂乙基亚硝脲处理的小鼠的一个家系中，已经发现了一种易患自发性肠癌的突变。突变基因被发现是显性表达和完全穿透的。受影响的小鼠在很小的时候就出现了整个肠道的多发性腺瘤。
In a pedigree derived from a mouse treated with the mutagen ethylnitrosourea, a mutation has been identified that predisposes to spontaneous intestinal cancer. The mutant gene was found to be dominantly expressed and fully penetrant. Affected mice developed multiple adenomas throughout the entire intestinal tract at an early age.