Coevolution of genomic intron number and splice sites
Coevolution of genomic intron number and splice sites
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DOI：
10.1016/j.tig.2007.04.001
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发表时间：
2007-07-01
影响因子：
11.4
通讯作者：
Roy, Scott W.
中科院分区：
文献类型：
--
作者：
Irimia, Manuel;Penny, David;Roy, Scott W.
真核生物中剪接体内含子的数目和边界序列差异很大。我们发现在真核生物基因组中，低内含子数和5'剪接位点（5' ss）的强序列保守性之间存在惊人的对应关系。系统发育模式表明，祖先的5'SS相对较弱的保守，但一些谱系独立地经历了主要的内含子丢失和5'SS加强。真核生物的祖先似乎有相对较大的内含子数量和“弱”的5'ss，这是一种与现代生物中频繁的选择性剪接相关的模式。
Spliceosomal intron numbers and boundary sequences vary dramatically in eukaryotes. We found a striking correspondence between low intron number and strong sequence conservation of 5' splice sites (5'ss) across eukaryotic genomes. The phylogenetic pattern suggests that ancestral 5'ss were relatively weakly conserved, but that some lineages independently underwent both major intron loss and 5'ss strengthening. It seems that eukaryotic ancestors had relatively large intron numbers and 'weak' 5'ss, a pattern associated with frequent alternative splicing in modern organisms.