NPY Y1 receptor like immunoreactivity exists in a subpopulation of beta-endorphin immunoreactive nerve cells in the arcuate nucleus: A double immunolabelling analysis in the rat
NPY Y1 receptor like immunoreactivity exists in a subpopulation of beta-endorphin immunoreactive nerve cells in the arcuate nucleus: A double immunolabelling analysis in the rat
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DOI：
10.1016/s0304-3940(97)00184-5
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发表时间：
1997-03-28
影响因子：
2.5
通讯作者：
Agnati, LF
中科院分区：
文献类型：
--
作者：
Fuxe, K;Tinner, B;Agnati, LF
免疫组织化学双标记表明，在大鼠弓状核神经肽Y（NPY）Y1受体样免疫反应是强烈存在于β-内啡肽免疫反应神经细胞体的亚群，而小的NPY免疫反应神经细胞体位于内侧缺乏NPY Y1受体样免疫反应。NPY Y1样神经元胞体分布于富含NPY阳性神经末梢的弓形区，形成均匀的神经丛。据推测，β-内啡肽神经元中的NPY Y1受体可能介导NPY对动机过程和疼痛控制以及垂体激素分泌的某些作用，至少部分涉及结节漏斗DA神经元的调节（C）1997 Elsevier Science爱尔兰Ltd.
Double immunolabelling immunohistochemistry in the arcuate nucleus of the rat demonstrates that neuropeptide Y (NPY) Y1 receptor like immunoreactivity is strongly present in a subpopulation of beta-endorphin immunoreactive nerve cell bodies, while the small NPY immunoreactive nerve cell bodies located medially lack NPY Y1 receptor like immunoreactivity. The NPY Y1 like immunoreactive nerve cell bodies lie in an arcuate area rich in NPY immunoreactive nerve terminals forming an uniform plexus. It is postulated that NPY Y1 receptors in beta-endorphin neurons may mediate some actions of NPY on motivational processes and pain control as well as on hypophyseal hormone secretion, involving at the least in part a regulation of the tubero-infundibular DA neurons (C) 1997 Elsevier Science Ireland Ltd.