Disconnection of medial agranular and posterior parietal cortex produces multimodal neglect in rats
Disconnection of medial agranular and posterior parietal cortex produces multimodal neglect in rats
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DOI：
10.1016/s0166-4328(96)02241-3
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发表时间：
1997-06-01
影响因子：
2.7
通讯作者：
Reep, RL
中科院分区：
文献类型：
--
作者：
Burcham, KJ;Corwin, JV;Reep, RL
大鼠的两个皮层区域在定向注意和空间处理中很重要：内侧无颗粒皮层（AGm），啮齿动物的额叶眼场模拟;后顶叶皮层（PPC），灵长类动物的第7区的啮齿动物模拟。在灵长类动物中，单侧破坏这些皮层联合区中的任何一个都会产生严重的视觉、听觉和触觉刺激的对侧忽视。AGm和PPC通过在皮质的第VI层中行进的纵向定向的轴突互连。他们的轨迹提供了一个独特的机会来检查这两个领域断开的影响。关键的问题是，这两个区域是独立发挥作用，还是作为定向注意的皮层网络的组成部分。PPC和AGm的单侧断开是通过横向刀切延伸通过VI层皮质。并通过跟踪方法验证断开。刀切产生严重的多模态忽视和异感/运动异常。刀伤造成的赤字与单方面破坏这些地区造成的赤字几乎相同。控制操作，其中收到刀削减，节省了AGm和PPC之间的互连，没有受到损害。结果表明，AGm和PPC在大鼠的功能作为一个部分的皮层系统的定向注意。(C)1997年Elsevier Science B.V.
Two cortical areas in rats have been found to be important in directed attention and spatial processing: the medial agranular cortex (AGm), the rodent analog of the frontal eye fields; and the posterior parietal cortex (PPC), the rodent analog of area 7 in primates. As in primates, unilateral destruction of either of these cortical association areas produces severe contralesional neglect of visual, auditory, and tactile stimulation. AGm and PPC are reciprocally interconnected by longitudinally oriented axons traveling in layer VI of the cortex. Their trajectory provides a unique opportunity to examine the effects of disconnection of these two areas. The key question is whether these two regions function independently or as components of a cortical network for directed attention. Unilateral disconnection of the PPC and AGm was achieved via transverse knife-cuts extending through layer VI of cortex. and the disconnection verified by tract-tracing methods. The knife-cuts produced severe multimodal neglect and allesthesia/allokinesia. The deficits produced by the knife-cuts were virtually identical to those produced by unilateral destruction of these regions. The control operates, which received knife-cuts that spared the interconnections between the AGm and PPC, were unimpaired. The results indicate that AGm and PPC in rats function as parts of a cortical system for directed attention. (C) 1997 Elsevier Science B.V.