Comparison of a drug versus money and drug versus drug self-administration choice procedure with oxycodone and morphine in opioid addicts.
Comparison of a drug versus money and drug versus drug self-administration choice procedure with oxycodone and morphine in opioid addicts.
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DOI：
10.1097/fbp.0b013e328363d1c4
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发表时间：
2013-09
影响因子：
1.6
通讯作者：
Saccone PA
中科院分区：
文献类型：
--
作者：
Comer SD;Metz VE;Cooper ZD;Kowalczyk WJ;Jones JD;Sullivan MA;Manubay JM;Vosburg SK;Smith ME;Peyser D;Saccone PA
这项双盲、安慰剂对照研究调查了口服吗啡（0、45、135 毫克/70 公斤）和口服羟考酮（0、15、45 毫克/70 公斤）对丁丙诺啡维持的阿片类药物成瘾者的影响。由于 3:1 的吗啡：羟考酮剂量比在非依赖性个体中产生了同等的主观和生理效应，因此本研究中使用了该比例。评估了两种自我管理实验室程序，即药物与金钱和药物与药物程序。研究参与者 (N=12) 住在医院并每天维持 4 毫克舌下含服丁丙诺啡。当参与者在药物和金钱之间做出选择时，金钱比所有药物剂量都更受青睐；只有高剂量羟考酮的自我施用量高于安慰剂。当参与者在药物和药物之间进行选择时，两种药物的选择多于安慰剂，每种药物的高剂量选择多于低剂量，高剂量羟考酮优于高剂量吗啡。与高剂量吗啡相比，高剂量羟考酮的主观、表现受损和缩瞳作用通常更大。研究表明吗啡：羟考酮 3:1 的剂量比对于丁丙诺啡依赖性受试者的效果并不相同。两种自我给药程序均可有效评估药物的相对强化作用；对一种程序的偏好应由感兴趣的具体研究问题驱动。
This double-blind, placebo-controlled study investigated effects of oral morphine (0, 45, 135 mg/70kg) and oral oxycodone (0, 15, 45 mg/70kg) in buprenorphine-maintained opioid addicts. Since a 3:1 morphine:oxycodone dose ratio had yielded equivalent subjective and physiological effects in non-dependent individuals, this ratio was used in the present study. Two self-administration laboratory procedures, i.e. a drug vs. money and a drug vs. drug procedure, were assessed. Study participants (N=12) lived in the hospital and were maintained on 4 mg/day sublingual buprenorphine. When participants chose between drug and money, money was preferred over all drug doses; only high-dose oxycodone was self-administered more than placebo. When participants chose between drug and drug, both drugs were chosen more than placebo, high doses of each drug were chosen over low doses, and high-dose oxycodone was preferred over high-dose morphine. The subjective, performance-impairing, and miotic effects of high-dose oxycodone were generally greater compared to high-dose morphine. The study demonstrated that a 3:1 dose ratio of morphine:oxycodone was not equipotent in buprenorphine-dependent subjects. Both self-administration procedures were effective for assessing the relative reinforcing effects of drugs; preference for one procedure should be driven by the specific research question of interest.