Reduced nicotine content cigarettes and nicotine patch.
Reduced nicotine content cigarettes and nicotine patch.
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DOI：
10.1158/1055-9965.epi-12-1439
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发表时间：
2013-06
期刊：
影响因子：
--
通讯作者：
Allen SS
中科院分区：
文献类型：
--
作者：
Hatsukami DK;Hertsgaard LA;Vogel RI;Jensen JA;Murphy SE;Hecht SS;Carmella SG;al'Absi M;Joseph AM;Allen SS
尼古丁含量(RNC)香烟的减少导致吸烟减少，戒断缓解，并促进戒烟。本研究的目的是考察RNC香烟单独使用尼古丁贴片和不使用尼古丁贴片对吸烟行为、毒物暴露、戒断不适的影响，并作为探索性分析，对长期戒烟进行研究。这项研究采用随机平行对照设计，共6周：1)0.05-0.09 mg尼古丁香烟(N=79)；2)21 mg尼古丁贴片(N=80)或3)0.05-0.09尼古丁含量香烟加21 mg尼古丁贴片(N=76)；所有组都接受了6周的额外行为治疗，并进行了长达6个月的随访。与单独使用RNC香烟相比，联合吸烟者吸烟率更低，因此CO水平更低。此外，与其他方法相比，与其他方法相比，联合方法在从通常品牌切换到指定产品时戒断严重程度较低，并且在治疗期间较少吸烟通常品牌香烟，但在治疗后并非如此。将尼古丁含量极低的香烟与尼古丁贴片结合起来，可能会改善单独使用这两种产品中的任何一种所产生的急性影响。这些发现可能会对戒烟治疗或减少香烟中尼古丁含量的政策措施产生影响。
Reduced nicotine content (RNC) cigarettes have led to smoking fewer cigarettes, withdrawal relief, and facilitation of cessation. The aim of this study is to examine the effects RNC cigarettes with and without nicotine patch and patch alone on smoking behavior, toxicant exposure, withdrawal discomfort and as an exploratory analysis, on long-term abstinence. This study involved a randomized, parallel arm design and six weeks of: 1) 0.05-0.09 mg nicotine yield cigarettes (N=79); 2) 21 mg nicotine patch (N=80) or 3) 0.05-0.09 nicotine yield cigarettes with 21 mg nicotine patch (N=76); all groups received six weeks of additional behavioral treatment with follow-ups up to six months. Combination approach led to lower rates of smoking assigned cigarettes and hence lower CO levels than RNC cigarettes alone. Additionally, the combination approach was associated with less withdrawal severity when switching from usual brand to assigned product, and less smoking of usual brand cigarettes during treatment, but not after treatment compared to the other approaches. Combining very low nicotine content cigarettes with nicotine patch may improve the acute effects resulting from switching to either of these products alone. These findings may have implications for smoking cessation treatment or a policy measure to reduce nicotine content in cigarettes.