Journey of the iodide transporter NIS: from its molecular identification to its clinical role in cancer.
Journey of the iodide transporter NIS: from its molecular identification to its clinical role in cancer.
复制标题
碘化物转运蛋白 NIS 的历程：从分子鉴定到其在癌症中的临床作用。
DOI：
10.1016/s0968-0004(01)01904-1
复制
发表时间：
2001
影响因子：
13.8
通讯作者：
Carrasco,N
中科院分区：
文献类型：
--
作者：
Riedel,C;Dohán,O;DelaVieja,A;Ginter,CS;Carrasco,N
The Na+/I−symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of I−in the thyroid, lactating mammary gland, stomach and salivary glands. The presence of NIS in the thyroid is exploited in diagnostic scintigraphic imaging and radioiodide therapy in thyroid cancer. The continued rapid progress in NIS research (aimed at the elucidation of the Na+-dependent I−transport mechanism, the analysis of NIS structure–function relations and the study of the tissue-specific regulation of NIS at all levels), holds potentially far-reaching medical applications beyond thyroid disease, in breast cancer and malignancies in other tissues.
