Arterial pulsation and lymph formation in an isolated sheep hindlimb preparation.
Arterial pulsation and lymph formation in an isolated sheep hindlimb preparation.
复制标题
离体羊后肢制剂中的动脉搏动和淋巴形成。
DOI：
10.1113/jphysiol.1988.sp017350
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
K. Thornbury
中科院分区：
文献类型：
--
作者：
J. Mcgeown;N. McHale;K. Thornbury
1.通过在绵羊后肢中的跖骨血管中插管来测量淋巴流量。通过在飞节远端插管的胫-颅动脉灌注温热的肝素化氧合血。比较了恒定和脉动灌注压。在跖骨上充气袖带以将静脉压维持在20 mmHg。2.在80 mmHg下恒定灌注期间的淋巴流率与完整跖骨制备中的对照流相当，并且水肿（通过测量组织体积监测）未累积。流量记录类似于从麻醉动物，淋巴被定期淋巴收缩排出。3.使用120/60 mmHg的脉动灌注（收缩期袖带周期0.25 s充气，0.5 s放气）未增加淋巴液流速。将脉压增加至100 mmHg（150/50 mmHg）可使血流增加20%，但无统计学显著性。使用120/60 mmHg时，袖带放气时间也增加（1 s充气，1 s放气），但影响不大。4.可以得出结论，动脉搏动对该制备中的淋巴形成并不重要。
1. Lymph flow was measured by cannulating metatarsal lymphatics in the sheep hindlimb. The region was perfused with warmed, heparinized, oxygenated blood via the tibio‐cranial artery cannulated just distal to the hock. Constant and pulsatile perfusion pressures were compared. A cuff was inflated over the metatarsals to maintain venous pressure at 20 mmHg. 2. The lymph flow rates during constant perfusion at 80 mmHg were comparable to control flows in intact metatarsal preparations and oedema (monitored by measuring tissue volume) did not accumulate. Flow records were similar to those obtained from anaesthetized animals, lymph being expelled by regular lymphatic contractions. 3. Pulsatile perfusion using 120/60 mmHg (systolic cuff cycle 0.25 s inflation, 0.5 s deflation) did not increase the rate of lymph flow. Increasing the pulse pressure to 100 mmHg (150/50 mmHg) produced a 20% increase in flow but this was not statistically significant. The cuff deflation time was also increased (1 s inflation, 1 s deflation) using 120/60 mmHg but this had little effect. 4. It may be concluded that arterial pulsation is not important for lymph formation in this preparation.
影响因子：
3.1
作者：
Skalak,TC;Schmid-Schönbein,GW;Zweifach,BW
通讯作者：
Zweifach,BW
血管运动、组织液流动和淋巴液的形成。
DOI：
--
发表时间：
1982
期刊：
International journal of microcirculation, clinical and experimental
影响因子：
--
作者：
Intaglietta,M;Gross,JF
通讯作者：
Gross,JF