Functional organization of squirrel monkey primary auditory cortex: Responses to pure tones
Functional organization of squirrel monkey primary auditory cortex: Responses to pure tones
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DOI：
10.1152/jn.2001.85.4.1732
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发表时间：
2001-04-01
影响因子：
2.5
通讯作者：
Schreiner, CE
中科院分区：
文献类型：
--
作者：
Cheung, SW;Bedenbaugh, PH;Schreiner, CE
用纯音刺激的兴奋性感受野测定了松鼠猴颞回初级听觉皮层（AI）反应参数的空间组织。四只动物的颞回密集微电极映射显示，特征频率（CF）具有平滑的单调梯度，从尾腹象限的较低值（0.5 kHz）到吻背象限的较高值（5-6 kHz）系统地变化。颞回的AI范围在吻尾轴上为4 mm，在背腹轴上为2-3 mm。低于6 kHz的Isolation轮廓的整个长度可用于研究。几个独立的，空间组织的功能反应参数被证明为松鼠猴AI。潜伏期，渐增的声压级在CF尖峰的最小到达时间，地形组织为一个单调的梯度跨AI几乎正交的CF梯度。头侧AI的潜伏期较长（范围= 4 ms）。阈值和带宽随CF共同变化。排除CF对阈值方差的贡献，残余阈值显示出跨AI的单调梯度，其尾侧具有更高的值（范围= 10 dB）。阈值梯度的方向与CF梯度显著不同。CF校正的带宽，残余Q10，在空间上组织在局部补丁的相干值，其位点是特定的每只猴子。这些数据支持人工智能中存在多个叠加的感受野梯度，并形成了开发概念框架的基础，以理解哺乳动物中简单和复杂的声音编码。
The spatial organization of response parameters in squirrel monkey primary auditory cortex (AI) accessible on the temporal gyrus was determined with the excitatory receptive field to pure tone stimuli. Dense, microelectrode mapping of the temporal gyrus in four animals revealed that characteristic frequency (CF) had a smooth, monotonic gradient that systematically changed from lower values (0.5 kHz) in the caudoventral quadrant to higher values (5-6 kHz) in the rostrodorsal quadrant. The extent of AI on the temporal gyrus was similar to4 mm in the rostrocaudal axis and 2-3 mm in the dorsoventral axis. The entire length of isofrequency contours below 6 kHz was accessible for study. Several independent, spatially organized functional response parameters were demonstrated for the squirrel monkey AI. Latency, the asymptotic minimum arrival time for spikes with increasing sound pressure levels at CF, was topographically organized as a monotonic gradient across AI nearly orthogonal to the CF gradient. Rostral AI had longer latencies (range = 4 ms). Threshold and bandwidth co-varied with the CF. Factoring out the contribution of the CF on threshold variance, residual threshold showed a monotonic gradient across AI that had higher values (range = 10 dB) caudally. The orientation of the threshold gradient was significantly different from the CF gradient. CF-corrected bandwidth, residual Q10, was spatially organized in local patches of coherent values whose loci were specific for each monkey. These data support the existence of multiple, overlying receptive field gradients within AI and form the basis to develop a conceptual framework to understand simple and complex sound coding in mammals.