Melanocytorrhagy and apoptosis in vitiligo: Connecting jigsaw pieces
Melanocytorrhagy and apoptosis in vitiligo: Connecting jigsaw pieces
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DOI：
10.4103/0378-6323.90942
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发表时间：
2012-01-01
影响因子：
2.9
通讯作者：
Parsad, Davinder
中科院分区：
文献类型：
--
作者：
Kumar, Ravinder;Parsad, Davinder
白癜风是一种获得性色素脱失性疾病，其特征是表皮和毛囊库中黑素细胞的慢性进行性损失。黑色素细胞消失的机制从未被清楚地了解。这篇综述讨论了支持黑素细胞增多和细胞凋亡作为黑素细胞损失的主要缺陷之一这一理论的数据。黑素细胞增多症理论提出，非节段性白癜风是一种原发性黑素细胞增多症，其对摩擦和可能的其他类型的压力的黑素细胞反应改变，导致其脱离和随后的经表皮损失。黑素细胞脱离诱导细胞凋亡，而粘附到基底膜则抑制细胞凋亡。对细胞凋亡、其诱导机制以及阻止细胞凋亡的方法的研究是寻找色素脱失原因和预防其进展的药物的一种可能方法。
Vitiligo is an acquired depigmenting disorder characterized by a chronic and progressive loss of melanocytes from the epidermis and follicular reservoir. The mechanism of melanocyte disappearance has never been clearly understood. This review discussed the data supporting the theory of melanocytorrhagy and apoptosis as one of the primary defects underlying melanocyte loss. Theory of melanocytorrhagy proposes that non-segmental vitiligo is a primary melanocytorrhagic disorder with altered melanocyte responses to friction and possibly other types of stress, inducing their detachment and subsequent transepidermal loss. Melanocytes detachment induces apoptosis whereas adherence to basement membrane suppresses apoptosis. The study of apoptosis, mechanisms of its induction, and the ways to block apoptosis is one possible way to find both the causes of depigmentation and medications to prevent its progression.