Enantiomerically pure rhodium complexes bearing 1,5-diphenyl-1,5-cyclooctadiene as a chiral diene ligand. Their use as catalysts for asymmetric 1,4-addition of phenylzinc chloride
Enantiomerically pure rhodium complexes bearing 1,5-diphenyl-1,5-cyclooctadiene as a chiral diene ligand. Their use as catalysts for asymmetric 1,4-addition of phenylzinc chloride
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DOI：
10.1021/ol0524914
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发表时间：
2005-12-22
期刊：
影响因子：
5.2
通讯作者：
Hayashi, T
中科院分区：
文献类型：
--
作者：
Kina, A;Ueyama, K;Hayashi, T
通过对非对映异构体[Rh(Ph-cod)((R)-1，1‘-binaphthyl-2，2’-diamine)]BF4.的光学拆分，得到了一种与1，5-二苯基-1，5-环辛二烯(Ph-Cod)配位的Rh配合物[RhCl((R)-Ph-Cod)](2)在氯三甲基硅烷存在下，苯基氯化锌与α，β-不饱和酮和酯的不对称1，4-加成反应中，具有高催化活性和对映体选择性(最高达98%ee)。
A rhodium complex coordinated with 1,5-diphenyl-1,5-cyclooctadiene (Ph-cod), [RhCl((R)-Ph-cod)](2), was obtained enantiomerically pure through optical resolution of diastereomeric isomers [Rh(Ph-cod)((R)-1,1'-binaphthyl-2,2'-diamine)]BF4. The enantiomerically pure rhodium complexes showed high catalytic activity and enantioselectivity (up to 98% ee) in the asymmetric 1,4-addition of phenylzinc chloride to alpha,beta-unsaturated ketones and esters in the presence of chlorotrimethylsilane.