Age differences in the response to the formalin test in rats
Age differences in the response to the formalin test in rats
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DOI：
10.1016/s0197-4580(99)00061-5
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发表时间：
1999-11-01
影响因子：
4.2
通讯作者：
Melzack, R
中科院分区：
文献类型：
--
作者：
Gagliese, L;Melzack, R
我们报告了一项研究的结果，该研究旨在评估对福尔马林试验（一种组织损伤和炎症模型）反应的年龄差异，同时控制三组成年雄性Long-Evans大鼠的体重和运动能力差异：年轻（3个月大），中年（18个月大）和老年（24个月大）。研究的第一部分评估了反应性的初始差异，发现中年组的反应最大，而年轻组和老年组之间没有差异。在研究的第二部分，对年轻和中年动物进行了为期4个月的随访。每隔2个月重复福尔马林试验。这些结果表明，对强直性疼痛的敏感性可能存在与年龄相关的变化，并且这种敏感性可能在中年达到峰值。(C)2000 Elsevier Science Inc. All rights reserved.
We report the results of a study designed to assess age differences in the response to the formalin test, a model of tissue injury and inflammation, while controlling for differences in weight and motoric abilities in three groups of adult male Long-Evans rats: young (3 months old), middle-aged (18 months old), and old (24 months old). The first part of the study assessed initial differences in responsivity and found that the middle-aged group showed the greatest response, whereas the young and old groups did not differ from each other. In the second part of the study, the young and middle-aged animals were followed for a 4-month period. The formalin test was repeated at 2-month intervals. These results indicate that there may he an age-associated change in the sensitivity to tonic pain and that this sensitivity may peak at mid-life. (C) 2000 Elsevier Science Inc. All rights reserved.