Comparative Screening of Digestion Tract Toxic Genes in Proteus mirabilis.
Comparative Screening of Digestion Tract Toxic Genes in Proteus mirabilis.
复制标题
奇异变形杆菌消化道毒性基因的比较筛选。
DOI：
10.1371/journal.pone.0151873
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Huang S
中科院分区：
文献类型：
--
作者：
Shi X;Lin Y;Qiu Y;Li Y;Jiang M;Chen Q;Jiang Y;Yuan J;Cao H;Hu Q;Huang S
奇异变形杆菌是一种常见的泌尿道致病菌，可引起多种炎症症状。其臭名昭著的耐多种抗生素和形成尿路结石的能力使得其治疗成为一个漫长而痛苦的过程，这进一步受到奇异变形杆菌基因组中频繁的水平基因转移事件的挑战。从深圳地区一起食物中毒事件中分离到3株奇异变形杆菌C 02011/C 04010/C 04013。我们的假设是，新的基因可能已经获得水平发挥消化道感染和毒性。这三个基因组的功能特征表明，它们各自独立地从其他微生物基因组水平获得数十个毒性基因。代表菌株C 02011引起呕吐和腹泻的症状，并且最近从其他细菌获得了完整的IV型分泌系统和消化道毒性基因。
Proteus mirabilis is a common urinary tract pathogen, and may induce various inflammation symptoms. Its notorious ability to resist multiple antibiotics and to form urinary tract stones makes its treatment a long and painful process, which is further challenged by the frequent horizontal gene transferring events in P. mirabilis genomes. Three strains of P. mirabilis C02011/C04010/C04013 were isolated from a local outbreak of a food poisoning event in Shenzhen, China. Our hypothesis is that new genes may have been acquired horizontally to exert the digestion tract infection and toxicity. The functional characterization of these three genomes shows that each of them independently acquired dozens of virulent genes horizontally from the other microbial genomes. The representative strain C02011 induces the symptoms of both vomit and diarrhea, and has recently acquired a complete type IV secretion system and digestion tract toxic genes from the other bacteria.