New Mycobacterium avium antifolate shows synergistic effect when used in combination with dihydropteroate synthase inhibitors.
New Mycobacterium avium antifolate shows synergistic effect when used in combination with dihydropteroate synthase inhibitors.
复制标题
新型鸟分枝杆菌抗叶酸剂与二氢蝶酸合酶抑制剂联合使用时显示出协同效应。
DOI：
10.1128/aac.49.11.4801-4803.2005
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Barrow,WW
中科院分区：
文献类型：
--
作者：
Suling,WJ;Seitz,LE;Reynolds,RC;Barrow,WW
鸟分枝杆菌复合群（MAC）对细菌二氢叶酸还原酶（DHFR）抑制剂甲氧苄啶耐药。先前鉴定的MAC DHFR的选择性抑制剂SRI-8858显示与氨苯砜和磺胺甲恶唑（两种抑制细菌二氢蝶酸合酶的药物）组合具有协同活性。
Mycobacterium aviumcomplex (MAC) is resistant to trimethoprim, an inhibitor of bacterial dihydrofolate reductase (DHFR). A previously identified selective inhibitor of MAC DHFR, SRI-8858, was shown to have synergistic activity in combination with dapsone and sulfamethoxazole, two drugs that inhibit bacterial dihydropteroate synthase.