How tissue damage MET metabolism: Regulation of the systemic damage response.
How tissue damage MET metabolism: Regulation of the systemic damage response.
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DOI：
10.1080/19336934.2016.1221549
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发表时间：
2017-01-02
期刊：
影响因子：
1.2
通讯作者：
Miura M
中科院分区：
文献类型：
--
作者：
Kashio S;Obata F;Miura M
活着的生物体经历了来自周围环境和身体内部的组织损伤。组织修复/再生是由局部组织损伤触发的，以恢复受伤或丢失的身体部分。组织损伤会导致一系列反应，不仅是局部的，而且是远端组织的全身性反应。在我们最近的出版物中，我们建立了一个“双重系统”，在周围组织中同时诱导时空组织损伤和基因操作。利用这个系统，我们证明了果蝇翼盘的组织修复需要对脂肪体中蛋氨酸代谢的适当调节，从而强调了系统损伤反应(SDR)在组织修复中的重要性。这篇“额外的观点”旨在讨论我们最近的报告，这些报告提出蛋氨酸代谢是SDR的重要组成部分，以及几个模式生物中的相关主题。
Living organisms experience tissue damage from both, the surrounding environment and from inside their bodies. Tissue repair/regeneration is triggered by local tissue injury to restore an injured, or lost, part of the body. Tissue damage results in a series of responses, not only locally but also systemically in distant tissues. In our recent publication, we established a “dual system” that induces spatiotemporal tissue damage simultaneously with gene manipulation in surrounding tissues. With this system, we demonstrated that appropriate regulation of methionine metabolism in the fat body is required for tissue repair in Drosophila wing discs, thus highlighting the importance of systemic damage response (SDR) in tissue repair. This “Extra View” aims to discuss our recent reports that propose methionine metabolism to be an essential part of SDR, together with related topics in several model organisms.