Light-scattering studies on bile acid salts I: Pattern of self-association of sodium cholate, sodium glycocholate, and sodium taurocholate in aqueous electrolyte solutions.
Light-scattering studies on bile acid salts I: Pattern of self-association of sodium cholate, sodium glycocholate, and sodium taurocholate in aqueous electrolyte solutions.
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胆汁酸盐的光散射研究 I：电解质水溶液中胆酸钠、甘氨胆酸钠和牛磺胆酸钠的自缔合模式。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
J. Cardinal
中科院分区：
文献类型：
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作者：
Y. Chang;J. Cardinal
利用光散射技术研究了三羟基胆汁盐在电解质水溶液中的缔合模式。胆汁盐胆酸钠、牛磺胆酸钠和甘氨胆酸钠的浊度在25 ℃下在0-25 mg/ml的浓度范围内测定。对于胆酸钠，支持电解质的浓度在0.15至0.5 M之间变化。对于0.15 M电解质中的所有胆汁盐，在氟化钠、氯化钠、溴化钠和碘化钠中测定浊度。光散射数据与单体胶束模型的比较表明，获得了定性的协议，但是，不能实现定量协议。对数据的进一步检查表明，光散射结果与包括二聚体、三聚体和含有约8个单体单元的更高聚集体的模型非常一致。
The pattern of association of the trihydroxy bile salts in aqueous electrolyte solutions was investigated utilizing the light-scattering technique. The turbidity of the bile salts sodium cholate, sodium taurocholate, and sodium glycocholate was determined over the concentration range of 0-25 mg/ml at 25 degrees. For sodium cholate, the concentration of the supporting electrolyte was varied from 0.15 to 0.5 M. For all bile salts in 0.15 M electrolyte, the turbidity was determined in sodium fluoride, sodium chloride, sodium bromide, and sodium iodide. Comparison of the light-scattering data with amonomer-micellar model showed that qualitative agreement was obtained; however, quantitative agreement could not be achieved. Further examination of the data showed that the light-scattering results were in good agreement with a model that includes dimers, trimers, and a higher aggregate containing approximately eight monomeric units.