Dietary flavonoids: Intake, health effects and bioavailability
Dietary flavonoids: Intake, health effects and bioavailability
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DOI：
10.1016/s0278-6915(99)00079-4
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发表时间：
1999-09-01
影响因子：
4.3
通讯作者：
Katan, MB
中科院分区：
文献类型：
--
作者：
Hollman, PCH;Katan, MB
黄酮类化合物是多酚类化合物，普遍存在于植物源性食品中。已经描述了超过4000种不同的类黄酮。由于它们的抗氧化特性和在动物研究中肿瘤发展的各个阶段的抑制作用，它们可能具有有益的健康作用。总黄酮摄入量的估计是困难的，因为只有有限的数据，食物的内容。据估计，人类每天摄入几百毫克。在荷兰，黄酮醇和黄酮类亚类的平均摄入量为23毫克/天。在大多数但不是所有的前瞻性流行病学研究中，黄酮醇和黄酮的摄入与随后的冠心病呈负相关。只有一项前瞻性研究发现黄酮醇对癌症有保护作用。食物中存在的风味物质被认为是不可吸收的，因为它们与糖结合为β-糖苷。然而，我们发现人类对洋葱中槲皮素糖苷的吸收（52%）远远好于纯糖苷配基（24%）。黄酮醇糖苷可能有助于血液的抗氧化防御。膳食黄酮醇和黄酮可能无法解释蔬菜和水果的抗癌作用;对心血管疾病的保护作用还没有定论。(C)1999 Elsevier Science Ltd.保留所有权利。
Flavonoids are polyphenolic compounds that occur ubiquitously in foods of plant origin. Over 4000 different flavonoids have been described. They may have beneficial health effects because of their antioxidant properties and their inhibitory role in Various stages of tumour development in animal studies. An estimation of the total flavonoid intake is difficult, because only limited data on food contents are available. It is estimated that humans ingest a few hundreds of milligram per day. The average intake of the subclasses of flavonols and flavones in The Netherlands was 23 mg/day. The intake of flavonols and flavones was inversely associated with subsequent coronary heart disease in most but not all prospective epidemiological studies. A protective effect of flavonols on cancer was found in only one prospective study. Flavonoids present in foods were considered non-absorbable because they are bound to sugars as beta-glycosides. However, we found that human absorption of the quercetin glycosides from onions (52%) is far better than that of the pure aglycone (24%). Flavonol glycosides might contribute to the antioxidant defences of blood. Dietary flavonols and flavones probably do not explain the cancer-protective effect of vegetables and fruits; a protective effect against cardiovascular disease is not conclusive. (C) 1999 Elsevier Science Ltd. All rights reserved.