Functional anatomy of impaired selective attention and compensatory processing in autism
Functional anatomy of impaired selective attention and compensatory processing in autism
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DOI：
10.1016/s0926-6410(03)00189-7
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发表时间：
2003-10-01
期刊：
影响因子：
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通讯作者：
Yurgelun-Todd, DA
中科院分区：
文献类型：
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作者：
Belmonte, MK;Yurgelun-Todd, DA
在自闭症中，即使在行为完好的情况下，选择性注意的生理指标也被证明是不正常的。这种行为和生理上的差异暗示了某种注意力代偿过程的作用，这可能为自闭症特征认知表型的病因学提供线索。对6名自闭症谱系障碍患者和6名正常对照者进行双侧视觉空间注意任务的功能磁共振成像研究。在正常科目中。该任务诱发了包括顶叶上在内的皮质区域网络的激活
In autism, physiological indices of selective attention have been shown to be abnormal even in situations where behaviour is intact. This divergence between behaviour and physiology suggests the action of some compensatory process of attention, one which may hold clues to the aetiology of autism's characteristic cognitive phenotype. Six subjects with autism spectrum disorders and six normal control subjects were studied with functional magnetic resonance imaging while performing a bilateral visual spatial attention task. In normal subjects. the task evoked activation in a network of cortical regions including the superior parietal lobe (P