Mechanisms of DNA oxidation
Mechanisms of DNA oxidation
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DOI：
10.1046/j.1525-1373.1999.d01-141.x
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发表时间：
1999-12-01
影响因子：
--
通讯作者：
Eveleigh, JF
中科院分区：
文献类型：
--
作者：
Aust, AE;Eveleigh, JF
由多种化学和物理因素引起的DNA氧化损伤似乎与癌症有关。然而，越来越清楚的是，内源性产生的氧化剂，如羟基自由基和过氧亚硝酸盐，会导致DNA氧化，这可能会在没有明显暴露于已知致癌的化学或物理试剂的个体中导致癌症。我们将讨论这两种氧化剂在生物体中产生的机制，并介绍它们与DNA反应产生氧化产物（例如8-oxo-dG）的活性，特别强调每种氧化剂产生的个体特征和反应活性。
Oxidative damage of DNA caused by a variety of chemical and physical agents appears to be linked to cancer. However, it is becoming increasingly clear that endogenous generation of oxidants, such as hydroxyl radical and peroxynitrite, lead to oxidation of DNA, and this may cause cancer in individuals where no obvious exposure to chemical or physical agents known to be carcinogenic has occurred. The mechanisms for generation of these two oxidants in living organisms will be discussed and their reactivities with DNA to produce oxidized products (e.g., 8-oxo-dG) will be presented with special emphasis on the individual characteristics of the generation and reactivity of each oxidant.