EVIDENCE FOR A SUPERANTIGEN MEDIATED PROCESS IN KAWASAKI-DISEASE
EVIDENCE FOR A SUPERANTIGEN MEDIATED PROCESS IN KAWASAKI-DISEASE
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DOI：
10.1136/adc.72.4.308
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发表时间：
1995-04-01
影响因子：
5.2
通讯作者：
LEVIN, M
中科院分区：
文献类型：
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作者：
CURTIS, N;ZHENG, R;LEVIN, M
川崎病与葡萄球菌和链球菌中毒性休克综合征之间的临床、病理和免疫学相似性表明，超抗原毒素可能参与该疾病的发病机制。使用 V β 2、5、8、12 和 19 的单克隆抗体检查了 21 名川崎病儿童、28 名患有其他疾病的儿童和 22 名健康对照者的外周血单核细胞 V β 谱。与健康对照或患有其他疾病的儿童相比，川崎病患者中表达 V β 2 的 T 细胞的平均百分比有所增加。与健康对照相比，川崎病患者表达 V beta 5、8、12 和 19 的 T 细胞的平均百分比也有所增加，但与患有其他疾病的儿童相比并未增加。 V beta 2 的选择性使用支持了超抗原参与川崎病发病机制的假设。
The clinical, pathological, and immunological similarities between Kawasaki disease and the staphylococcal and streptococcal toxic shock syndromes suggest that a superantigen toxin may be involved in the pathogenesis of the disease. The V beta repertoire of peripheral blood mononuclear cells from 21 children with Kawasaki disease, 28 children with other illnesses, and 22 healthy controls were examined using monoclonal antibodies to V beta 2, 5, 8, 12, and 19. The mean percentage of V beta 2 expressing T cells in the patients with Kawasaki disease was increased when compared with healthy controls or children with other illnesses. The mean percentages of V beta 5, 8, 12, and 19 expressing T cells were also increased in the patients with Kawasaki disease compared with healthy controls, but were not increased when compared with children with other illnesses. The selective use of V beta 2 supports the hypothesis that a superantigen is involved in the pathogenesis of Kawasaki disease.