Microbubble-Assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System
Microbubble-Assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System
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DOI：
10.1007/978-3-319-22536-4_16
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发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Hynynen, Kullervo
中科院分区：
文献类型：
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作者：
Burgess, Alison;Hynynen, Kullervo
血脑屏障是对脑部疾病（包括癌症、神经退行性疾病和神经精神疾病）的药物治疗的严重障碍。聚焦超声与微泡结合，已成为瞬时和局部打开血脑屏障以促进药物递送到大脑的有效方法。聚焦超声已被用于成功地将各种治疗剂递送至临床前疾病模型。聚焦超声技术的临床翻译的要求。
The blood-brain barrier is a serious impediment to the delivery of pharmaceutical treatments for brain diseases, including cancer, neurodegenerative and neuropsychatric diseases. Focused ultrasound, when combined with microbubbles, has emerged as an effective method to transiently and locally open the blood-brain barrier to promote drug delivery to the brain. Focused ultrasound has been used to successfully deliver a wide variety of therapeutic agents to pre-clinical disease models. The requirement for clinical translation of focused ultrasound technology is considered.