The structural biology of type IV secretion systems.

The structural biology of type IV secretion systems.
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DOI:
10.1038/nrmicro2218
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发表时间:
2009-10
期刊:
Nature reviews. Microbiology
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IV型分泌系统(t4ss)是一种多功能的分泌系统,存在于革兰氏阴性和革兰氏阳性细菌中,分泌多种底物,从单一蛋白质到蛋白质-蛋白质和蛋白质- dna复合物。它们通常由12个组分组成,这些组分被组织成atp供电的双膜复合物。单个可溶组分或结构域的结构已经解决了,但是对这些结构如何结合在一起的理解直到最近才开始出现。这篇综述的重点是在过去的十年中所取得的结构进展,以及相应的结构见解如何帮助阐明IV型分泌机制的许多细节。
Type IV secretion systems (T4SSs) are versatile secretion systems that are found in both Gram-negative and Gram-positive bacteria and secrete a wide range of substrates, from single proteins to protein–protein and protein–DNA complexes. They usually consist of 12 components that are organized into ATP-powered, double-membrane-spanning complexes. The structures of single soluble components or domains have been solved, but an understanding of how these structures come together has only recently begun to emerge. This Review focuses on the structural advances that have been made over the past 10 years and how the corresponding structural insights have helped to elucidate many of the details of the mechanism of type IV secretion.
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