Association between Oral Health Status and Diabetic Nephropathy-Related Indices in Japanese Middle-Aged Men
Association between Oral Health Status and Diabetic Nephropathy-Related Indices in Japanese Middle-Aged Men
复制标题
日本中年男性口腔健康状况与糖尿病肾病相关指数的关联
DOI：
10.1155/2020/4042129
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发表时间：
2020
影响因子：
4.3
通讯作者：
Hinode Daisuke
中科院分区：
文献类型：
--
作者：
Yoshioka Masami;Okamoto Yoshifumi;Murata Masahiro;Fukui Makoto;Yanagisawa Shizuko;Shirayama Yasuhiko;Nagai Kojiro;Hinode Daisuke
口腔健康状况与生活方式相关的疾病，如糖尿病和慢性肾脏疾病有关。在日本，大约40%的血液透析病例是糖尿病肾病患者。本研究的目的是阐明日本中年男性口腔健康状况与糖尿病肾病相关指标之间的关系。66名男性（年龄范围：55-64岁），剩余牙齿≥20颗，接受过公共医疗检查和口腔检查。我们检查了年龄、体重指数、HbA1c、HDL - C、LDL - C、中性脂肪、血清肌酐和肾小球滤过率（eGFR）与剩余牙齿数量或社区牙周指数（CPI）评分（牙周袋< 4mm: 0,4 - 6mm: 1,≥6mm: 2）的相关性。CPI评分与血清肌酐呈正相关，与eGFR呈负相关（Spearman等级相关系数，r= 0.459,p< 0.01, r= - 0.460,p< 0.01）。CPI评分0分组的平均eGFR显著高于CPI评分1/2分组（82.6 vs. 70.7, Student 'st - test,p< 0.01）。以eGFR为因变量，年龄、CPI评分、体重指数、HbA1c、中性脂肪为自变量的Logistic回归分析表明，eGFR低（<60）可归因于CPI评分（OR = 3.169, 95% CI: 1.031-9.742,p= 0.044）。这些结果提示日本中年男性牙周状况与肾功能之间可能存在关联。牙周病是通过口腔预防控制的，牙周病和慢性肾脏疾病有一些共同的危险因素。因此，牙周管理有助于预防严重的慢性肾脏疾病。
Oral health status is known to be associated with lifestyle‐related diseases such as diabetes and chronic kidney disease. In Japan, around 40% of hemodialysis cases are patients with diabetic nephropathy. The aim of this study was to clarify the association between oral health status and diabetic nephropathy‐related indices in Japanese middle‐aged men. Sixty‐six men (age range: 55–64 years) with ≥20 remaining teeth and who received public medical checkups and oral examinations were enrolled. We examined correlations of age, body mass index, HbA1c, HDL‐C, LDL‐C, neutral fat, serum creatinine, and the estimated glomerular filtration rate (eGFR) with the number of remaining teeth or the community periodontal index (CPI) score (periodontal pocket < 4 mm: 0, 4–6 mm: 1, ≥6 mm: 2). A positive correlation between the CPI score and serum creatinine and a negative correlation between CPI score and eGFR (Spearman’s rank correlation coefficient,r= 0.459,p< 0.01, andr= −0.460,p< 0.01, respectively) were observed. The mean eGFR in the CPI score 0 group was significantly higher than that in the CPI score 1/2 group (82.6 vs. 70.7, Student’st‐test,p< 0.01). Logistic regression analysis using eGFR as a dependent variable and age, CPI score, body mass index, HbA1c, and neutral fat as independent variables suggested that low eGFR (<60) could be attributed to CPI score (OR = 3.169, 95% CI: 1.031–9.742,p= 0.044). These results suggest a possible association between periodontal status and renal function in Japanese middle‐aged men. Periodontal condition is controlled by oral prophylaxis, and periodontal disease and chronic kidney disease have some common risk factors. Thus, periodontal management can contribute to the prevention of severe chronic kidney disease.