Membrane adhesion and other functions for the myelin basic proteins.
Membrane adhesion and other functions for the myelin basic proteins.
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膜粘附等功能为髓磷脂碱性蛋白。
DOI：
10.1002/bies.950180106
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Pedraza,L
中科院分区：
文献类型：
--
作者：
Staugaitis,SM;Colman,DR;Pedraza,L
髓鞘碱性蛋白是一组在髓鞘形成过程中起重要作用的外周膜多肽。它们最广为人知的特性是具有独特的能力，可以“封闭”髓鞘细胞膜的细胞质，但这可能不是这些高电荷分子的唯一功能。尽管具有广泛的同源性，但单个髓鞘碱性蛋白(MBP)表现出不同的表达模式和生化特性，因此现在认为不同的亚型在髓鞘细胞中功能不同。我们现在认为，虽然主要的MBPs是细胞内的黏附分子，但一些在发育早期表达的数量较少的异构体可能对髓鞘形成程序具有调节作用。
The myelin basic proteins are a set of peripheral membrane polypeptides which play an essential role in myelination. Their most well‐documented property is the unique ability to ‘seal’ the cytoplasmic aspects of the myelin membrane, but this is probably not the only function for these highly charged molecules. Despite extensive homology, the individual myelin basic proteins (MBPs) exhibit different expression patterns and biochemical properties, and so it is now believed that the various isoforms are not functionally equivalent in myelinating cells. We now think that while the major MBPs are intracellular adhesion molecules, some of the quantitatively less abundant isoforms that are expressed very early in development may have regulatory effects on the myelination program.