Kinetic characteristics of cerebral gliomas.
Kinetic characteristics of cerebral gliomas.
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脑胶质瘤的动力学特征。
DOI：
10.1093/neurosurgery/25.cn_suppl_1.326
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
C. Wilson
中科院分区：
文献类型：
--
作者：
T. Hoshino;C. Wilson
每一个神经外科医生都知道，胶质瘤，除了某些小脑和视神经星形细胞瘤，表现出进行性生长，恶性胶质瘤，如多形性胶质母细胞瘤，间变性星形细胞瘤和髓母细胞瘤，生长速度比分化良好的（星形细胞瘤，少突胶质细胞瘤，室管膜瘤等）。神经胶质瘤，并证明在较短的时间内致命。受现有诊断程序的限制，过去大多数外科医生认为每个胶质母细胞瘤细胞可能每隔1或2个月分裂一次，因为这种肿瘤在达到可检测的大小后每隔1或2个月体积就会增加一倍（4，11）。以及用于检测标记分子的亚细胞位置的放射自显影术的引入，已经导致了大量的实验研究，这些研究已经阐明了正常和肿瘤组织中细胞增殖的各种模式。胸苷是在细胞分裂准备期间专门用于复制脱氧核糖核酸（DNA）的一种核苷酸。当氚标记的胸苷（3 H-TdR）可用于细胞群时，它被合成DNA的细胞吸收，随后这些细胞很容易通过放射自显影法鉴定（22）。3 H-TdR结合数学分析的复杂使用已经阐明了静态和扩展组织的细胞和组织动力学，其定义为总体群体生长。
Every neurosurgeon knows that gliomas, with the exception of certain cerebellar and optic astrocytomas, exhibit progressive growth, and that malignant gliomas, such as glioblastoma multiforme, anaplastic astrocytoma, and medulloblastoma, grow faster than well-differentiated (fibrillary astrocytoma, oligodendroglioma, ependymoma, etc.) gliomas and prove fatal in a shorter period of time. Limited by available diagnostic procedures, in the past most surgeons have assumed that each glioblastoma cell might divide every 1 or 2 months, since such a tumor doubles its volume every 1 or 2 months after it has reached a detectable size (4, 11).Synthesis of radioactive nucleotides, especially 3H-thymidine at Brookhaven in 1957 (24), as well as the introduction of autoradiography for the detection of the subcellular location of labeled molecules, have led to a large number of experimental studies that have clarified various patterns of cell proliferation in normal and neoplastic tissues. Thymidine is the one nucleotide that is used exclusively to duplicate deoxyribonucleic acid (DNA) during preparation for cell division. When tritium-labeled thymidine (3H-TdR) is made available to a population of cells, it is taken up by those cells synthesizing DNA, and subsequently those cells are readily identified by autoradiography (22). Sophisticated use of 3H-TdR combined with mathematical analyses has elucidated the cell and tissue kinetics of both static and expanding tissues, defined in terms of overall population growth.