The Ugly Duckling Turned to Swan: A Change in Perception of Bystander-Activated Memory CD8 T Cells.
The Ugly Duckling Turned to Swan: A Change in Perception of Bystander-Activated Memory CD8 T Cells.
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DOI：
10.4049/jimmunol.2000937
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发表时间：
2021-02-01
期刊：
影响因子：
--
通讯作者：
Prlic M
中科院分区：
文献类型：
--
作者：
Maurice NJ;Taber AK;Prlic M
记忆T细胞（Tmem）在再次遇到病原体时迅速产生ag特异性反应。然而，在没有激活TCR信号的情况下，Tmem也会对炎症信号做出反应，这种现象被称为旁观者激活。虽然旁观者激活在20多年前首次被描述，但T细胞旁观者激活的生理相关性和后果在最近几年才变得更加明显。在这里，我们回顾了触发CD8 Tmem旁观者激活的情况，包括全身性或局部性的急性和慢性感染，以及肿瘤内和接种疫苗后旁观者CD8 Tmem的证据。我们总结了旁观者激活对T细胞本身、随后的免疫反应和宿主的可能后果。我们强调了T细胞旁观者激活何时对宿主有利或有害，并简要讨论了我们目前在控制旁观者激活的调节信号方面的知识差距。
Memory T cells (Tmem) rapidly mount Ag-specific responses during pathogen reencounter. However, Tmem also respond to inflammatory cues in the absence of an activating TCR signal, a phenomenon termed bystander activation. While bystander activation was first described over 20 years ago, the physiological relevance and the consequences of T cell bystander activation have only become more evident in recent years. Here we review the scenarios that trigger CD8 Tmem bystander activation including acute and chronic infections that are either systemic or localized, as well as evidence for bystander CD8 Tmem within tumors and following vaccination. We summarize the possible consequences of bystander activation for the T cell itself, the subsequent immune response, and the host. We highlight when T cell bystander activation appears to benefit or harm the host and briefly discuss our current knowledge gaps regarding regulatory signals that can control bystander activation.
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影响因子：
32.4
作者：
Chng, Melissa Hui Yen;Lim, Mei Qiu;Newell, Evan W.
通讯作者：
Newell, Evan W.
DOI：
10.1084/jem.20031051
发表时间：
2003-11-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Berg RE;Crossley E;Murray S;Forman J
通讯作者：
Forman J
影响因子：
8.8
作者：
Chu T;Tyznik AJ;Roepke S;Berkley AM;Woodward-Davis A;Pattacini L;Bevan MJ;Zehn D;Prlic M
通讯作者：
Prlic M
影响因子：
7.2
作者：
Braun, Matthias;Ress, Marie L.;Woelfl, Matthias
通讯作者：
Woelfl, Matthias
影响因子：
4.4
作者：
Ely, KH;Cauley, LS;Woodland, DL
通讯作者：
Woodland, DL