Trends in incidence and prognosis for head and neck cancer in the United States: A site-specific analysis of the SEER database
Trends in incidence and prognosis for head and neck cancer in the United States: A site-specific analysis of the SEER database
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DOI：
10.1002/ijc.20740
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发表时间：
2005-05-01
影响因子：
6.4
通讯作者：
Kowalski, LP
中科院分区：
文献类型：
--
作者：
Carvalho, AL;Nishimoto, IN;Kowalski, LP
尽管最近头颈癌的诊断和治疗取得了进展，但在过去几十年里，几乎没有证据表明5年生存率有所提高。为了更准确地确定特定部位结果的趋势，而不是对头颈癌患者进行更全面的概述，我们分析了1973-1999年监测、流行病学和最终结果- seer公共使用数据库中收集的特定部位数据。根据选择标准，对96232例患者进行发病率、临床分期、治疗和5年生存率的趋势分析。在1973年至1999年期间，头颈癌的特定地点发病率发生了显著变化。1974-1997年的特异性生存分析显示，鼻咽癌、口咽癌和下咽癌的5年生存率显著提高（鼻咽癌为38.1%至56.7%,p < 0.001；口咽癌为36.3%至49.1%,p = 0.001；下咽癌为28.3%至33.3%,p = 0.015）。1983-1997年早期涎腺癌和1974-1997年晚期喉癌的预后也有改善（分别为82.7% ~ 88.5%,p = 0.012和22.2% ~ 38.3%,p = 0.013）。另一方面，区域期口腔癌和早期喉癌患者的预后在1983 ~ 1997年间下降（分别为49.2% ~ 43.8%,p = 0.032和82.3% ~ 74.3%,p = 0.002）。治疗和分期的部位特异性变化也被注意到。部位特异性分析可以更准确地描述头颈癌的发病率、分期、治疗和预后趋势。(C) 2004 Wiley-Liss, Inc。
Despite recent advances in the diagnosis and treatment of head and neck cancer, there has been little evidence of improvement in 5-year survival rates over the last few decades. To determine more accurate trends in site-specific outcomes as opposed to a more general overview of head and neck cancer patients, we analyzed the site-specific data collected in the Surveillance, Epidemiology, and End Results-SEER Public-Use Database 1973-1999. Based on the selection criteria, 96,232 cases were evaluated for trend analysis in incidence, clinical stage, treatment and 5-year survival. During the period 1973-1999, site-specific incidence rates for head and neck cancer changed significantly. Site-specific analysis of survival from 1974-1997 showed significant improvements in 5-year survival rates for cancers of the nasopharynx, oropharynx and hypopharynx (38.1% to 56.7% for nasopharynx, p < 0.001; 36.3% to 49.1% for oropharynx, p = 0.001 and 28.3% to 33.3% for hypopharynx, p = 0.015). The prognosis for early-stage salivary gland cancer during 1983-1997 and late-stage larynx cancer during 1974-1997 also demonstrated improvement (82.7% to 88.5%,p = 0.012 and 22.2% to 38.3%,p = 0.013, respectively). On the other hand, the prognosis for regional stage oral cavity cancer as well as early-stage larynx cancer patients declined during 19831997 (49.2% to 43.8%, p = 0.032 and 82.3% to 74.3%, p = 0.002, respectively). Site-specific changes in treatment and staging were also noted. Site-specific analysis allows for a more accurate description of incidence, staging, treatment, and prognostic trends for head and neck cancer. (C) 2004 Wiley-Liss, Inc.