Recurrent cough in childhood and its relation to asthma.
Recurrent cough in childhood and its relation to asthma.
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儿童反复咳嗽及其与哮喘的关系。
DOI：
10.1164/ajrccm.153.4.8616551
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Martinez,FD
中科院分区：
文献类型：
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作者：
Wright,AL;Holberg,CJ;Morgan,WJ;Taussig,LM;Halonen,M;Martinez,FD
作为前瞻性纵向图森儿童呼吸研究的一部分，研究了儿童期复发性咳嗽（RC）的危险因素及其与哮喘的关系。RC定义为过去一年中咳嗽≥ 2次而无感冒，对987名6岁儿童进行问卷调查。无喘鸣的RC患儿（n = 154）与无喘鸣症状的患儿（n = 610）在血清IgE水平、皮试反应、大小校正用力呼气流量或冷空气激发后下降百分比方面无差异。与此相反，RC和喘息的儿童（n = 116）有显着更多的呼吸系统疾病，更过敏，较低的流量在潮气末呼气（V 'maxFRC），和更大的下降，肺功能冷空气挑战后，比没有症状的儿童。目前父母吸烟是RC无喘息的风险，而男性性别，母亲过敏，喘息性下呼吸道疾病（LRI）在生命早期，高IgE是RC喘息的显着风险，与儿童相比，没有症状。大多数儿童在2-3岁至6岁以及6岁至11岁之间的生命早期RC消退。高IgE和皮肤点刺试验阳性与6岁以下喘息儿童RC持续存在相关，过敏标志物与6 - 11岁RC持续存在相关。这些研究结果表明，在没有喘息的情况下，反复咳嗽在重要方面不同于经典哮喘，使用相同的标签来指代这些不同的综合征可能会掩盖其不同的病理生理学。
Risk factors for recurrent cough (RC) in childhood, and its relation to asthma were investigated as part of the prospective, longitudinal Tucson Children's Respiratory Study. RC, defined as > or = 2 episodes of cough without a cold in the past year, was assessed by questionnaire in 987 children at age 6. Children having RC without wheeze (n = 154) did not differ from children with neither symptom (n = 610) in serum IgE levels, skin test response, size-corrected forced expiratory flow, or percentage of decline following cold air challenge. In contrast, children with both RC and wheeze (n = 116) had significantly more respiratory illness, more atopy, lower flow at end-tidal expiration (V'maxFRC), and greater declines in lung function following cold air challenge than children with neither symptom. Current parental smoking was a risk for RC without wheeze, whereas male gender, maternal allergy, wheezing lower respiratory tract illness (LRI) in early life, and high IgE were significant risks for RC with wheeze, compared with children having neither symptom. RC early in life resolved in the majority of children, between ages 2-3 yr and age 6, and between age 6 and age 11. High IgE and positive skin prick test were associated with persistence of RC to age 6 among children who wheezed, and markers of allergy were associated with persistence of RC between 6 and 11 yr. These findings suggest that recurrent cough in the absence of wheeze differs in important respects from classic asthma, and using the same label to refer to these distinct syndromes may obscure their diverse pathophysiologies.