Testosterone Treatment of Men With Mild Cognitive Impairment and Low Testosterone Levels
Testosterone Treatment of Men With Mild Cognitive Impairment and Low Testosterone Levels
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DOI：
10.1177/1533317514556874
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发表时间：
2015-06-01
影响因子：
3.4
通讯作者：
Matsumoto, A. M.
中科院分区：
文献类型：
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作者：
Cherrier, M. M.;Anderson, K.;Matsumoto, A. M.
简介：本研究调查了睾酮 (T) 治疗对患有轻度认知障碍 (MCI) 和低血清 T 水平的男性认知、情绪和生活质量的影响。方法：对 351 名社区居住男性进行了筛查，其中 37 名男性同时表现出 MCI 和低 T 水平，其中 27 人同意进一步筛查。 22 名患者符合所有研究纳入/排除标准，并参加了一项为期 6 个月的随机、双盲、安慰剂对照研究。结果：T 治疗组的总 T 水平显着升高。在治疗组中，除了语言记忆的 1 项客观测量有所改善 (P < .05) 和抑郁症状减少 (P < .02) 之外，在认知、情绪或生活质量方面没有观察到显着变化。结论：睾酮治疗可能会适度改善 MCI 和低 T 男性的语言记忆和抑郁症状。
Introduction: This study investigated the effects of testosterone (T) treatment on cognition, mood, and quality of life in men with mild cognitive impairment (MCI) and low serum T levels.Methods: A total of 351 community-dwelling men were screened, and 37 men evidenced both MCI and low T of whom 27 agreed for further screening. Twenty-two met all the study inclusion/exclusion criteria and enrolled in a 6-month randomized, double-blind, placebo-controlled study.Results: Total T levels significantly increased in the T treatment group. No significant changes were observed in measures of cognition, mood, or quality of life other than improvement in 1 objective measure of verbal memory (P < .05) and decreased depression symptoms (P < .02) in the treatment group.Conclusions: Testosterone treatment may modestly improve verbal memory and depression symptoms in men with both MCI and low T.