INFLUENCE OF MORPHINE ON RESPIRATORY ACTIVITIES OF PHRENIC AND HYPOGLOSSAL NERVES IN CATS
INFLUENCE OF MORPHINE ON RESPIRATORY ACTIVITIES OF PHRENIC AND HYPOGLOSSAL NERVES IN CATS
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DOI：
10.1016/0034-5687(86)90122-2
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发表时间：
1986-06-01
期刊：
影响因子：
--
通讯作者：
STJOHN, WM
中科院分区：
文献类型：
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作者：
BARTLETT, D;STJOHN, WM
麻醉和镇静药物对舌下神经的呼吸运动活性的影响比对膈神经的影响更大。这种上呼吸道运动活动的差异性抑制可能是镇静药物加重阻塞性睡眠呼吸暂停的原因之一。为了确定吗啡是否具有类似的选择性作用，我们记录了去大脑、迷走神经切断、加拉胺麻痹的猫在吗啡给药前后的膈神经和舌下神经活动。在大多数动物中，吗啡降低了这两条神经的活动，但反应是高度可变的，没有明显的差异抑郁的一致模式。结果的可变性可能反映了阿片类药物对呼吸控制作用的复杂性。
Anesthetic and sedative drugs have been found to diminish the respiratory motor activity of the hypoglossal nerve more than that of the phrenic nerve. This differential depression of motor activity to the upper airway may contribute to the exacerbation of obstructive sleep apnea by sedative drugs. To determine whether morphine has a similar selective action, we recorded phrenic and hypoglossal nerve activities before and after morphine administration in decerebrate, vagotomized cats, paralyzed with gallamine. Morphine diminished the activities of both nerves in most animals, but the responses were highly variable, and no consistent pattern of differential depression was apparent. The variability of the results may reflect the complex nature of opiate actions on the control of breathing.