WOMEN AT RISK: SOCIOECONOMIC STATUS, LIFESTYLE FACTORS, AND BRAIN VULNERABILITY AMONG JAPANESE AND SWEDISH FEMALE
WOMEN AT RISK: SOCIOECONOMIC STATUS, LIFESTYLE FACTORS, AND BRAIN VULNERABILITY AMONG JAPANESE AND SWEDISH FEMALE
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DOI：
10.1093/geroni/igac059.2909
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发表时间：
2022-12-20
影响因子：
7
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虽然多种可改变的生活方式因素和疾病管理已被强调用于预防痴呆症和改善神经退行性疾病，但妇女和社会经济地位不利的人群仍然承受着不成比例的负担。目的：调查和比较SES的潜在途径，生活方式因素，成像生物标志物和认知在两个社区居住队列在日本和瑞典。主题：熊本队列包括576名认知健康女性（73.66 ± 5.96岁）;桦木队列包括195名认知健康女性（63.91 ± 13.41岁）。我们构建了结构方程模型的生活方式因素，包括运动，社会活动，睡眠，饮酒和吸烟状况;疾病状况包括肥胖，糖尿病，高血压和抑郁症;脑成像生物标志物包括区域同性恋物质体积（GMV）和皮质厚度从T1加权磁共振成像扫描和整体认知评分。我们还研究了SES相关的灰质体积和皮质厚度地图的位置在整个大脑水平。SES与边缘叶GMV（而非皮质厚度）呈正相关，熊本队列：标准化直接β =0.21（0.13;0.28）;桦木队列：标准化直接β =0.27（0.13; 0.41）。在熊本队列中，疾病状况和生活方式介导了这种SES-GMV关联：间接β =-0.013（0.001; 0.054）。我们还发现几个区域，包括额内侧回，额上级回，海马和丘脑，在两个队列中通常对SES状态敏感。结论：虽然这项研究的观察性质排除了因果关系的证据，但我们的研究结果表明，促进疾病管理对于解决面临SES差异的女性的神经退行性疾病负担至关重要。
While multiple modifiable lifestyle factors and disease management have been highlighted for preventing dementia and ameliorating neurodegeneration, women and the disadvantaged socioeconomic status (SES) population still bear disproportionate burdens. Objective: Investigate and compare the potential pathways of SES, lifestyle factors, imaging biomarkers, and cognition in two community dwelling cohorts in Japan and Sweden. Subjects: The Kumamoto Cohort included 576 cognitively healthy females (73.66 ± 5.96 years); the Betula Cohort included 195 cognitively healthy females (63.91 ± 13.41 years). We constructed structural equational modeling by lifestyle factors including exercise, social activity, sleep, drinking, and smoking status; disease conditions included obesity, diabetes, hypertension, and depressive disorder; brain imaging biomarkers included regional gay matter volume (GMV) and cortical thickness obtained from T1 weighted magnetic resonance imaging scans and global cognition score. We also examined SES-related gray matter volume and cortical thickness map locations at the whole brain level. SES was positively associated with GMV of limbic lobe (not cortical thickness), Kumamoto Cohort: standardized direct β =0.21 (0.13;0.28); Betula Cohort: standardized direct β =0.27 (0.13; 0.41). This SES-GMV association was mediated by disease conditions and lifestyle in Kumamoto Cohort: indirect β =-0.013 (0.001; 0.054). We also found several regions, including the medial frontal gyrus, superior frontal gyrus, hippocampus, and thalamus, were commonly sensitive to SES status in two cohorts. Conclusions: Although the observational nature of the study precludes proof of causality, our findings suggest that promoting disease management is crucial to tackling the neurodegeneration burden in the female facing SES disparities.