A genetic analysis of ambulatory cardiorespiratory coupling
A genetic analysis of ambulatory cardiorespiratory coupling
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DOI：
10.1111/j.1469-8986.2005.00276.x
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发表时间：
2005-03-01
期刊：
影响因子：
3.7
通讯作者：
De Geus, EJC
中科院分区：
文献类型：
--
作者：
Kupper, N;Willemsen, G;De Geus, EJC
本研究评估了动态心动周期、呼吸性窦性心律不齐（RSA）和呼吸频率的遗传性，并检验了这些变量之间的相关性是由常见遗传因素决定的假设。对780例健康双生子及同胞进行了24小时动态心电图和胸阻抗记录。遗传分析表明，在所有的日常时期，心脏周期（37%-48%），RSA（40%-55%）和呼吸频率（27%-81%）的遗传力相当大。在整个过程中发现了显着的遗传相关性。共同的基因解释了大部分的协方差之间的心脏周期和RSA之间的呼吸频率和RSA。在下午和夜间，呼吸速率与呼吸强度的协方差完全由共同基因决定。这种基因的重叠可以被利用来增加连锁研究的能力，以检测影响心血管疾病风险的遗传变异。
This study assessed the heritability of ambulatory heart period, respiratory sinus arrhythmia (RSA), and respiration rate and tested the hypothesis that the well-established correlation between these variables is determined by common genetic factors. In 780 healthy twins and siblings, 24-h ambulatory recordings of ECG and thorax impedance were made. Genetic analyses showed considerable heritability for heart period (37%-48%), RSA (40%-55%), and respiration rate (27%-81%) at all daily periods. Significant genetic correlations were found throughout. Common genes explained large portions of the covariance between heart period and RSA and between respiration rate and RSA. During the afternoon and night, the covariance between respiration rate and RSA was completely determined by common genes. This overlap in genes can be exploited to increase the power of linkage studies to detect genetic variation influencing cardiovascular disease risk.