Lymphatic tissue engineering - Progress and prospects
Lymphatic tissue engineering - Progress and prospects
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DOI：
10.1196/annals.1413.004
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Niklason, Laura
中科院分区：
文献类型：
--
作者：
Hitchcock, Thomas;Niklason, Laura
在过去的5年中，组织工程领域取得了重大进展。然而，虽然几乎所有主要系统的组织工程都得到了研究和改进，但在可行的淋巴组织工程方面却做得很少。淋巴生物学理解的最新进展已经允许容易地分离纯淋巴细胞培养物，从而增加了更详细地研究淋巴生物学的能力。这使得在结构、细胞和分子水平上阐明淋巴特性成为可能，使得第一个淋巴工程组织的成功开发成为可能。这些进展包括毛细淋巴管的工程化，设计用于体外培养淋巴结的功能生物反应器的开发，以及淋巴器官的体内生长。然而，还没有关于功能性淋巴管的工程化的研究。虽然淋巴生物学研究取得的进展令人鼓舞，但该系统的复杂性使得某些功能性淋巴组织的工程化变得更加困难。
In the last 5 years major advances have been made in the field of tissue engineering. However, while engineering of tissues from nearly every major system in the body have been studied and improved, little has been done with the engineering of viable lymphatic tissues. Recent advances in understanding of lymphatic biology have allowed the easy isolation of pure lymphatic cell cultures, increasing, in turn, the ability to study lymphatic biology in greater detail. This has allowed the elucidation of lymphatic properties on the structural, cellular, and molecular levels, making possible the successful development of the first lymphatic engineered tissues. Among such advances are the engineering of lymphatic capillaries, the development of a functioning bioreactor designed to culture lymph nodes in vitro, and in vivo growth of lymphatic organoids. However, there has been no research on the engineering of functional lymphangions. While the advances made in the study of lymphatic biology are encouraging, the complexities of the system make the engineering of certain functional lymphatic tissues somewhat more difficult.